UGC Approved Journal no 63975(19)

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Published in:

Volume 5 Issue 1
January-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1801027


Registration ID:
171235

Page Number

141-150

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Title

A Study of Method Development and Validation for Quantification of Iguratimod in Pharmaceutical Dosage Form by RP-HPLC Method

Abstract

A rapid and stability-indicating reversed phase high-performance liquid chromatography (RP-HPLC) method was developed for quantification of Iguratimod in the dosage form to get some more advantages over other methods already developed. The method was validated according to United States Pharmacopeia (USP) guideline with respect to accuracy, precision, specificity, linearity, solution stability, robustness and system suitability. For this, an isocratic condition of mobile phase comprising buffer (pH 2.5) and methanol in a ratio of 58:42, v/v at a flow rate of 1.2 mL/minute over Water symmetry C18, 150 × 3.9 mm, 5μm) column at 25°C temperature was maintained. The method showed excellent linear response with correlation coefficient (R2) values of 0.999 for Iguratimod, which was within the limit of correlation coefficient (R2≥0.995). The percent recovery was found within the acceptance limit of (97.0–103.0%). Intra-and inter-day precision studies of the new method were less than the maximum allowable limit percentage of relative standard deviation (%RSD≤2.0).

Key Words

RP-HPLC, Validation

Cite This Article

"A Study of Method Development and Validation for Quantification of Iguratimod in Pharmaceutical Dosage Form by RP-HPLC Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 1, page no.141-150, January-2018, Available :http://www.jetir.org/papers/JETIR1801027.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A Study of Method Development and Validation for Quantification of Iguratimod in Pharmaceutical Dosage Form by RP-HPLC Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 1, page no. pp141-150, January-2018, Available at : http://www.jetir.org/papers/JETIR1801027.pdf

Publication Details

Published Paper ID: JETIR1801027
Registration ID: 171235
Published In: Volume 5 | Issue 1 | Year January-2018
DOI (Digital Object Identifier):
Page No: 141-150
Country: Mumbai, Maharashtra, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication


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