• Sanjana Gaikwad
• Madhukar Tajne

Present study describes the formulation of Nano suspension System of Antimalarial Drugs Artemether and Lumefantrine with lipids and surfactants which enchanced the solubility and bioavailability. The poorly soluble drugs, were considered to be fit for nanosuspension to improve its solubility. The study intended to preparation of nano suspension by means ofZirconium beads milling method and furtherLyophillisation. Artemether Lumefantrine consists of PVP and SLS. Nanopowders were further characterized for particle size, Zeta Potential and Drug contentwas to be 732.9 nm, -0.2 mV and 99.25 %. During the screening processes, the formulation showed a smaller particle size and stability during lyophilization.In vitrostudies reported to be90.34±0.21% for Artemether and 92.03±0.72%for Lumefantrine. The in vitropercent drug release of Artemether and Lumefantrine from Nanopowder found to be higher as compared to marketed formulation (Lumerax®) and pure drugs. The Drug Excipient compatibility studies carried by FT-IR and XRD depicted that there was no interaction between drugs and excipients.Moreover it was suggested that stabilizersPVP and SLS were appreciated excipients on the Nanopowder platform and exhibited the abilities of size-reduction and stability-maintaining on freeze-drying

Anti-malarials, Nanosuspension, Freeze drying, enhanced solubility, dissolution, Oral bioavailability

"Optimization, Characterization of Artemether and Lumefantrine Nanosuspension for Solubility and Bioavailability Enhancement", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 6, page no.777-792, June-2016, Available :http://www.jetir.org/papers/JETIR1701161.pdf

"Optimization, Characterization of Artemether and Lumefantrine Nanosuspension for Solubility and Bioavailability Enhancement", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 6, page no. pp777-792, June-2016, Available at : http://www.jetir.org/papers/JETIR1701161.pdf