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Pathophysiology, Diagnosis and Management of Diabetic Neuropathy: A Review

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Diabetic neuropathies are a family of nerve disorders caused by chronic effect of diabetes. It is the most common complication and greatest source of morbidity and mortality in diabetics. The main risk factor for diabetic neuropathy is hyperglycemia. It can affect nerves throughout the body, causing numbness and sometimes pain in the hands, arms, feet, or legs, and problems with the digestive tract, heart, sex organs, and other body systems. The pathology of diabetic neuropathy involves oxidative stress, advanced glycation end products, polyol pathway flux and protein kinase C activation; all contribute to microvascular disease and nerve dysfunction. Management of Diabetic neuropathy first involves bringing blood glucose levels within the normal range. Its treatment includes pain relief and other medications as needed, depending on the type of nerve damage. Foot care is an important part of treatment. Untreated injuries increase the risk of infected foot sores and amputation.

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Neuropathy, Hyperglycemia, Peripheral Nerves, Microvasculature, Foot amputation.

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"Pathophysiology, Diagnosis and Management of Diabetic Neuropathy: A Review", International Journal of Emerging Technologies and Innovative Research ( | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 1, page no. pp125-129, January-2018, Available at : &

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Published Paper ID: JETIR1801023
Registration ID: 171232
Published In: Volume 5 | Issue 1 | Year January-2018
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Page No: 125-129
ISSN Number: 2349-5162

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UGC and ISSN Approved Journal | Call For Paper
(Volume 5 | Issue 1 | January 2018 |Impact factor 5.87)

Call For Paper | Volume 5 | Issue 1 | Impact factor 5.87

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