UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 5 Issue 6
June-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1806677


Registration ID:
184141

Page Number

554-560

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Title

HISTONE DEACETYLASES (HDACs) CLASS II GENES AS POTENTIAL DRUG TARGETS IN CANCER

Abstract

Abstract: This review has been undertaken to investigate the role of histone deacetylases (HDACs) class II genes in various cancers. Efforts in cancer research mainly aims to identify the major drug targets, develop and improve treatment regimens which eventually helps into better prognosis. One of the major challenges is the determination and mapping of involvement of molecular pathways. So, there has been large interest in developing pathways and also determining driver genes and regulators. Bioinformatics helps to evaluate huge data from wetlab researches to explore biologically relevant interactions and pathways. Emerging evidence shows that many HDACs exists as biomarkers in cancers. The objective of this study is to present a review on the major and latest findings on class II HDACs and its association in cancers. Here, we summarize the current knowledge of class II HDACs, including their features and classification, biological mechanism as well as their function and reported clinical studies in cancers. In addition, we discuss various trials and clinically available inhibitors targeting them. These results provide valuable insights which helps to identify and develop cancer specific therapeutic options.

Key Words

HDACs, epigenetics, cancer pathways, bioinformatics, drug target identification

Cite This Article

"HISTONE DEACETYLASES (HDACs) CLASS II GENES AS POTENTIAL DRUG TARGETS IN CANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 6, page no.554-560, June-2018, Available :http://www.jetir.org/papers/JETIR1806677.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"HISTONE DEACETYLASES (HDACs) CLASS II GENES AS POTENTIAL DRUG TARGETS IN CANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 6, page no. pp554-560, June-2018, Available at : http://www.jetir.org/papers/JETIR1806677.pdf

Publication Details

Published Paper ID: JETIR1806677
Registration ID: 184141
Published In: Volume 5 | Issue 6 | Year June-2018
DOI (Digital Object Identifier):
Page No: 554-560
Country: Hyderabad, Telangana, India .
Area: Science & Technology
ISSN Number: 2349-5162
Publisher: IJ Publication


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