• Manish Mishra
• Govinda Verma

A simple, precise and specific spectroscopy method for quantitative determination of Linagliptin in API and in pharmaceutical dosage form was developed and validated. Linagliptin showed maximum absorbance at 295 nm by using distilled water as a solvent. The method shows linear relationship in the concentration range of (1-10µg/ml). The regression equation of linearity curve was found to be y = 0.0903x + 0.0278and correlation coefficient (R2) was found to be0.998. The precision of the method was found to be within %RSD ≤ 2.Method accuracy was observed as 100.69±0.41.No interference was found in the absorbance of drug in the presence of common excipients and analysis conditions. This method was validated and applied to the determination of Linagliptin in pharmaceutical dosage form.

UV Spectroscopy, Calibration curve method, Linagliptin

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF LINAGLIPTIN IN BULK AND DOSAGE FORM BY UV SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.908-912, July-2018, Available :http://www.jetir.org/papers/JETIR1807863.pdf

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF LINAGLIPTIN IN BULK AND DOSAGE FORM BY UV SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp908-912, July-2018, Available at : http://www.jetir.org/papers/JETIR1807863.pdf