• Sayantan Mukhopadhyay
• Jyotsana Bhatt
• Preeti Kothiyal

Alzheimer’s disease is a progressive neurodegenerative disorder affecting about a large number of population worldwide. Increasing prevalence of alzheimer’s lead to new innovations in the field of pharmaceutics for better delivery of drug to the target site i.e. brain. The aim of the present study is development and evaluation of donepezil hydrochloride loaded nanoparticles for efficient management of Alzheimer’s disease. Modified solvent evaporation technique was utilized for the preparation of polymeric nanoparticles. Drug (Donepezil hydrochloride) & polymers (Eudragit S100 and Eudragit RS100) were taken in different ratios for preparing six formulations. The prepared nanoformulations were subjected to different evaluation parameters. After characterization these formulations were added to carbopol gel to prepare nanoparticulated gel for further study. On the basis of various evaluation parameters formulation FS1 was selected as the optimized formulation with particle size 195.9nm, percentage yield 47%, zeta potential -19.2, PDI as 0.642, % and percentage release as 84.41% in 24 hrs. The formulation FS1 followed zero order kinetic with supercase II diffusion respectively. Thus, concluding that the prepared donepezil hydrochloride loaded polymeric nanoparticles can be used efficiently to deliver drug to the brain for effective management of Alzheimer’s.

Alzheimer’s disease, Polymeric nanoparticles, modified solvent evaporation technique, spreadability study

"Development and Evaluation of Polymeric Nanoparticles of Donepezil Hydrochloride for Efficient Management of Alzheimer’s disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.488-497, August-2018, Available :http://www.jetir.org/papers/JETIR1808825.pdf

"Development and Evaluation of Polymeric Nanoparticles of Donepezil Hydrochloride for Efficient Management of Alzheimer’s disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp488-497, August-2018, Available at : http://www.jetir.org/papers/JETIR1808825.pdf