• Jatin thorat

A high performance thin layer chromatography (HPTLC) Stability indicating method was developed and validated for determination of anti-asthmatic drug .i. e. fluticasone propionate in API and Pharmaceutical formulation. Mobile phase consisting of Toluene:ethyl acetate (7:3) was used on pre-coated silica gel TLC plates for all studies. A TLC scanner in absorbance mode set at 239 nm was used for estimation of the chromatograms. ICH guidelines were used to validate developed method.Correlation coefficient (R2) of calibration curve was found to be 0.9995 in the range of 100–500 ng spot−1 for fluticasone, respectively. Limit of detection (LOD) and Limit of quantification (LOQ) for fluticasone were 40.78 and 70.24 ng/spot Method had an accuracy of 99.5 ±2%. Force degradation studies were carried out for acidic, basic, oxidative and thermal conditions .There was no any interference of drug and degradant peaks. Method has been used to determine quality analysis of fluticasone from its dosage

Densitometric detection, HPTLC, fluticasone propionate

"STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF FLUTICASONE PROPIONATE IN API AND PHARMACEUTICAL DOSAGE FORM BY HPTLC CHROMATOGRAPHIC TECHNIQUE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.503-514, August-2018, Available :http://www.jetir.org/papers/JETIR1808827.pdf

"STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF FLUTICASONE PROPIONATE IN API AND PHARMACEUTICAL DOSAGE FORM BY HPTLC CHROMATOGRAPHIC TECHNIQUE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp503-514, August-2018, Available at : http://www.jetir.org/papers/JETIR1808827.pdf