• Mutabazi Francois
• Mubano O.Clement
• Wang Honghua
• Tang Luhong

: Gossypol; a natural polyphenolic compound firstly extracted from cottonseeds oil has interestingly been reported to be an effective non-hormonal contraceptive agent, antimicrobial, and antiviral against human pathogenic bacteria, viruses, protozoa parasites and yeast-like microorganisms causing human infections including even some sexually transmitted infections (STIs). Multipurpose contraceptives are advanced drugs designed in one product indicated to prevent unwanted pregnancy and transmission of one or more STIs including HIV. More especially; the antifertility properties of gossypol combined with its multi-antimicrobial and antiviral properties may play a huge impact on reproductive health for further design and development of an effective multipurpose therapy providing a potential anti-infections protection and contraceptive barrier method. Gossypol and its derivatives showed complex chemical and biological properties with high reactivity through different mechanisms of action by which their various chemical forms exhibit polyvalent biological activities such as anticancer, antioxidant, antifertility, antimicrobial, antiviral, antiprotozoal, and antimalarial. This review discusses gossypol and its derivatives formation, synthesis, and current potential applications as an antifertility and anti-infections molecule.

gossypol, cottonseed, contraceptive, antifertility, microorganisms, antimicrobial.

"INSIGHTS ON SYNTHESIS AND POTENTIAL APPLICATIONS OF GOSSYPOL, A PROMISING MULTIPURPOSE CONTRACEPTIVE AND ANTI-INFECTIONS AGENT: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 10, page no.768-798, October-2018, Available :http://www.jetir.org/papers/JETIR1810900.pdf

"INSIGHTS ON SYNTHESIS AND POTENTIAL APPLICATIONS OF GOSSYPOL, A PROMISING MULTIPURPOSE CONTRACEPTIVE AND ANTI-INFECTIONS AGENT: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 10, page no. pp768-798, October-2018, Available at : http://www.jetir.org/papers/JETIR1810900.pdf