• Pramod B Thakur

An efficient and rapid synthesis of diversely functionalized bioxindole framework is described by the reaction of oxindoles with isatins using DABCO under aqueous medium. The generality of the reaction to afford the desired bioxindole framework is well demonstrated by screening different structurally varied oxindole nucleophiles as well as isatin electophiles. The scope of reaction was further strengthened by demonstrating its scale-up potential. Mild reaction condition, shorter reaction time, high isolated yield of the product with good diastereoselectivity, column chromatography-free purification, wide scope of substrate and environmentally benign medium are attractive features of the present protocol.

Isatin; Oxindole; DABCO; Bioxindole

"Rapid Construction of Bioxindole Frameworks Using DABCO Under Aqueous Reaction Media", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 11, page no.239-244, November-2018, Available :http://www.jetir.org/papers/JETIR1811935.pdf

"Rapid Construction of Bioxindole Frameworks Using DABCO Under Aqueous Reaction Media", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 11, page no. pp239-244, November-2018, Available at : http://www.jetir.org/papers/JETIR1811935.pdf