• Sumitra Poudel
• Arun Dev Pokharel
• Dr. Suman Samaddar
• Shambhu Chaudhary
• Samiat Owoaladea

Abstract Nothapodytes nimmoniana (Graham) Mabb is small tree, 3-8 m high belonging to family Icacinaceae is commonly known as Amruta and found in Maharashtra, Goa, Kerala, Karnataka, Assam and Tamil Nadu in India. The major source of a potent alkaloid, namely camptothecin (CPT) and 9-methoxy camptothecin, which is used in various types of cancer, HIV, malaria, antibacterial, anti-inflammatory, antifungal activity, immune modulator. It also contains 3-ketooctadec-cis-15-enoic acid, palmitic acid, stearic acid, oleic acid, linoleic acid and linolenic acid. Other chemical constituents isolated from this plant are acetylcamptothecin, (+)-1-hydroxypinoresinol, Ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-D-glucoside. Gentamicin which is the class of aminoglycoside antibiotics (AG) are widely used in the treatment of a variety of infections (ocular, pulmonary, and intestinal infections) produced by Gram-negative bacteria and bacterial endocarditis. Their cationic structure, which depends on the number of amino groups and on their distribution within the molecule, seems to have an important role in their toxicity, mostly affecting renal (nephrotoxicity) and hearing (ototoxicity) tissues in which they accumulate. Moreover, this aminoglycoside has been widely used as a model to study the nephrotoxicity.AndCCl4 is commonly used for free radical induced liver injury. Liver is not the only target organ of CCl4 but it also affects several organs of the body such as lungs, hearts, testes, kidneys and brain.It is generally accepted that CCl4 toxicity results from bioactivation of CCl4 into trichloromethyl free radical by cytochrome P450 system in liver microsomes and consequently causes lipid peroxidation of membranes that leads to liver toxicity.The nephroprotective and hepatoprotective activity of N. nimmoniana is probably due to the presence of Flavanoids& Alkaloid (camptothecin) in N. nimmoniana plant. Hence, the review of the study is concluded that the N. nimmoniana may possesses nephroprotective and hepatoprotective activity which gives many links to develop the future trials.

Nothapodytes nimmoniana,Nephroprotective activity, Hepatoprotectiveactivity, antioxidant activity.

"Review onNothapodytes nimmonianaand itsNephro Protective, Hepatoprotective and Anti- Oxidant Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 11, page no.436-443, November-2018, Available :http://www.jetir.org/papers/JETIR1811964.pdf

"Review onNothapodytes nimmonianaand itsNephro Protective, Hepatoprotective and Anti- Oxidant Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 11, page no. pp436-443, November-2018, Available at : http://www.jetir.org/papers/JETIR1811964.pdf