• SIMANCHAL PANDA

Caffeine is a drug isolated from Coffea arabica. The pure drug is an alkaloid categorized as Xanthine. Caffeine broadly used as CNS stimulant, analgesic, antipyretic and antipsychotic drug. As the pure drug is an alkaloid derivative it has bitter taste. Here the research work is an attempt to mask the bitter taste of drug by complexation. Betacyclodextrin polymer is used here as the complexing agent to mask taste of bitterness. The complexation resulted in enhancement of bioavailability and physical parameters.The most important property of a dosage form is its ability to deliver the active ingredient to its site of action in an amount sufficient to elicit the desired pharmacological response. Bioavailability is a measurement of the extent of a therapeutical active drug that reaches the systemic circulation and is available at the site of action. Accordingly, the absorption of an intravenously administered drug is instantaneous and complete. However, for reasons of convenience and stability, most drugs are administered orally after first being formulated in to dosage forms, usually tablets, capsule, nanosuspensions, naoemulsions etc. Various physicochemical, physiological, formulation and manufacturing variables affect the bioavailability of the drug from these orally administered dosage forms. Among the various factors that affect the bioavailability, it has now been recognized with certainly that dissolution behavior and the factor affecting such performance are of paramount importance in the design and evalution of nanosuspension. As early as 1955 parrot and coworker’s stressed that the release of a drug from the primary particle and its subsequent availability to the body is goverened by the dissolution rate of the particle. The properties of the dosage form that modify the dissolution rate must necessarily influence the blood level of the drug, and thus may function as the controlling factor in determining the magnitude of the pharmacological response elicited and sometimes even of determining whether or not such a response is exhibited at all. The pharmaceutical and medical literature is replete with report showing variability in clinical response among orally administered drug product that contains chemically equivalent amounts of a drug. Those drugs are usually of limited aqueous solubility and the variation has generally been attributed to differences in the rate of dissolution.

Keywords: Repaglinide, β-cyclodextrin, XRD, Complexation.

"TASTEMASKING OF CAFFEINE BY BETACYCLODEXTRINE AND FORMULATION EVALUATION OF NANO SUSPENSION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.474-484, January-2019, Available :http://www.jetir.org/papers/JETIR1901B62.pdf

"TASTEMASKING OF CAFFEINE BY BETACYCLODEXTRINE AND FORMULATION EVALUATION OF NANO SUSPENSION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp474-484, January-2019, Available at : http://www.jetir.org/papers/JETIR1901B62.pdf