• Dr Seema Mishra

Abstract- Diminished tissue sensitivity to insulin is a characteristic of various pathological conditions termed the insulin resistance syndrome, also known as the metabolic syndrome or cardio metabolic syndrome . The metabolic syndrome is not a single disease, but rather a complex cluster of symptoms that include a large waist circumference, hypertension, hyperglycemia, dyslipidemia and insulin resistance, all of which are commonly associated with increased risk of obesity and Hypertension, which is treatment resistant. Since patients with metabolic syndrome are commonly afflicted with cardiovascular morbidities, the metabolic syndrome and cardiovascular diseases share common pathways including increased oxidative stress, defective glucose, lipid metabolism, low grade inflammation, hypercoagulability and endothelial damage. Previously, investigators proposed to use the “circulatory syndrome” to refine the metabolic syndrome concept through the addition of markers of cardiovascular diseases such as renal impairment, microalbuminuria, arterial stiffness and left ventricular dysfunction. It has become increasingly obvious that insulin resistance and the efforts made by the insulin-targeted organs to compensate for this defect play a vital role in the pathogenesis and clinical course of the metabolic syndrome .Insulin resistance along with normal glucose tolerance capacity couples with fulminating cases of hypertension. Indian population is specially prone to this very problem. This case –control study collected and analyzed data regarding the coexistence of Hyperinsulinemia and Hypertension. A significant differences in terms of Lipid Profile , Blood Pressure , obesity and BMI was observed among Insulin Resistance subjects and controls with normal Insulin levels.

Key Words- Hyperinsulinemia, Blood Pressure , Lipid Profile, Waist Circumference , BMI

"HYPERTENSION DUE TO INSULIN RESISTANCE IN NON DIABETICS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.743-752, January-2019, Available :http://www.jetir.org/papers/JETIR1901B99.pdf

"HYPERTENSION DUE TO INSULIN RESISTANCE IN NON DIABETICS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp743-752, January-2019, Available at : http://www.jetir.org/papers/JETIR1901B99.pdf