UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 7 Issue 2
February-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2002279


Registration ID:
227896

Page Number

500-506

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Title

RESEARCH PAPER TITLE - FORMULATION AND EVALUATION OF SPHERICAL AGGLOMERATES OF CANDESARTAN CILEXETIL BY SOLVENT CHANGE METHOD

Abstract

Candesartan cilexetil, exhibits poor water solubility, poor flowability and poor dissolution. Study was focus on to improve the dissolution of Candesartan cilexetil. Spherical agglomerates containing Candesartan cilexetil was prepared by solvent change method. By using ternary phase diagram ratio of solvent addition was maintained. Drug was dissolved in methanol (good solvent), water (poor solvent), dichloromethane (bridging liquid) was used in the preparation. The produced drug particles were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). In vitro dissolution study of prepared particle was carried out. It was found that dissolution profile of all the batches were increased also micromeritic properties are increased. Appropriate amount of polymer addition and highest speed will give better drug release.

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"RESEARCH PAPER TITLE - FORMULATION AND EVALUATION OF SPHERICAL AGGLOMERATES OF CANDESARTAN CILEXETIL BY SOLVENT CHANGE METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.500-506, February-2020, Available :http://www.jetir.org/papers/JETIR2002279.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"RESEARCH PAPER TITLE - FORMULATION AND EVALUATION OF SPHERICAL AGGLOMERATES OF CANDESARTAN CILEXETIL BY SOLVENT CHANGE METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp500-506, February-2020, Available at : http://www.jetir.org/papers/JETIR2002279.pdf

Publication Details

Published Paper ID: JETIR2002279
Registration ID: 227896
Published In: Volume 7 | Issue 2 | Year February-2020
DOI (Digital Object Identifier):
Page No: 500-506
Country: -, -, -- .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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