• Pallavi M. Chaudhari
• Kiran S. Sale

The main objective of present work was to prepare and evaluate SLN based topical gel of Cromolyn sodium for treatment of inflammation. SLN were formulated by hot homogenization technique, by use of design expert software. The influence of independent variables lipid and surfactant on properties of SLN such as particle size and drug release, was studied using central composite design. The in-vitro drug release rate of gel was evaluated using franz diffusion cell containing cellophane membrane with phosphate buffer pH 6.8 as a medium. From all formulations and the results batch 7 was selected as an optimized batch that showed 95.04% drug release after 8 hr. The different parameters like pH, viscosity, spreadability are also evaluated. It is concluded that Cromolyn sodium loaded SLN based gel containing cocoa butter as a lipid and tween 80 as a surfactant was suitable for topical application and shows effective anti-inflammatory activity.

SLN, optimization, topical gel.

"FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.1337-1345, March-2020, Available :http://www.jetir.org/papers/JETIR2003198.pdf

"FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp1337-1345, March-2020, Available at : http://www.jetir.org/papers/JETIR2003198.pdf