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Published in:

Volume 7 Issue 3
March-2020
eISSN: 2349-5162

Unique Identifier

JETIR2003198

Page Number

1337-1345

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Title

FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY

ISSN

2349-5162

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"FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.1337-1345, March-2020, Available :http://www.jetir.org/papers/JETIR2003198.pdf

Abstract

The main objective of present work was to prepare and evaluate SLN based topical gel of Cromolyn sodium for treatment of inflammation. SLN were formulated by hot homogenization technique, by use of design expert software. The influence of independent variables lipid and surfactant on properties of SLN such as particle size and drug release, was studied using central composite design. The in-vitro drug release rate of gel was evaluated using franz diffusion cell containing cellophane membrane with phosphate buffer pH 6.8 as a medium. From all formulations and the results batch 7 was selected as an optimized batch that showed 95.04% drug release after 8 hr. The different parameters like pH, viscosity, spreadability are also evaluated. It is concluded that Cromolyn sodium loaded SLN based gel containing cocoa butter as a lipid and tween 80 as a surfactant was suitable for topical application and shows effective anti-inflammatory activity.

Key Words

SLN, optimization, topical gel.

Cite This Article

"FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp1337-1345, March-2020, Available at : http://www.jetir.org/papers/JETIR2003198.pdf

Publication Details

Published Paper ID: JETIR2003198
Registration ID: 229979
Published In: Volume 7 | Issue 3 | Year March-2020
DOI (Digital Object Identifier):
Page No: 1337-1345
ISSN Number: 2349-5162

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Cite This Article

"FORMULATION AND EVALUATION OF TOPICAL SLN BASED GEL OF CROMOLYN SODIUM FOR ANTI- INFLAMMATORY ACTIVITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp1337-1345, March-2020, Available at : http://www.jetir.org/papers/JETIR2003198.pdf




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