• Ms.manjusha gunjal
• Ms.minal rajebahadurr
• Ms.Archana Gaikwad

: Metoclopramide hydrochloride is used as dopamine receptor antagonist antiemetic and for achieving long term effect there is need to give Metoclopramide hydrochloride as sustained drug delivery.The objective of the present study was to formulate and evaluate floating microspheres for metoclopramide hydrochloride for prolonged buoyancy with sustained release of the drug into the gastric content. Metoclopramide hydrochloride loaded microspheres were prepared by the solvent evaporation method using 32 factorial design .all the formulation shows good micromeritic properties. Percentage yield of all formulation varied from 76.84% to 93.77% where F1 has 76.84% and F9 has 93.77%. This shows that as polymer conc. and rpm increases; percentage yield also increases. In vitro drug release of all formulation varied from 67.14% to 83.69%. The optimized formulation exhibited % drug entrapment efficiency of 88.82%, 73.99% of in vitro buoyancy after 12 hr and 80.31% drug release. From the solution for optimization as per Design Expert Software it can be concluded as F7 formulation is the best formulation

: Metoclopramide hydrochloride is used as dopamine receptor antagonist antiemetic and for achieving long term effect there is need to give Metoclopramide hydrochloride as sustained drug delivery.The objective of the present study was to formulate and evaluate floating microspheres for metoclopramide hydrochloride for prolonged buoyancy with sustained release of the drug into the gastric content. Metoclopramide hydrochloride loaded microspheres were prepared by the solvent evaporation method using 32 factorial design .all the formulation shows good micromeritic properties. Percentage yield of all formulation varied from 76.84% to 93.77% where F1 has 76.84% and F9 has 93.77%. This shows that as polymer conc. and rpm increases; percentage yield also increases. In vitro drug release of all formulation varied from 67.14% to 83.69%. The optimized formulation exhibited % drug entrapment efficiency of 88.82%, 73.99% of in vitro buoyancy after 12 hr and 80.31% drug release. From the solution for optimization as per Design Expert Software it can be concluded as F7 formulation is the best formulation

"Formulation and evaluation of Metoclopramide hydrochloride floating microsphere", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.203-214, May-2019, Available :http://www.jetir.org/papers/JETIR2003332.pdf

"Formulation and evaluation of Metoclopramide hydrochloride floating microsphere", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp203-214, May-2019, Available at : http://www.jetir.org/papers/JETIR2003332.pdf