• Dr. Rabindra Dey

Cyclodextrins (CYDs) are made up of 6, 7 and 8 glucopyranosyl units attached to α-(1, 4) - glycosidic linkages are identified as α, β, γ - cyclodextrins respectively. The CYDs are of biomedical and pharmaceutical interest are cyclic oligosaccharides composed of six to eight dextrose units connected through one to four bonds.The utilization of CYDs previously has an extended history in pharmaceuticals, pesticides, foodstuffs etc. for the solubility, bioavailability, safety, stability and as a transporter of the guest molecules. “Beta Cyclodextrin has been extensively used due to ready availability but it has some demerits like low solubility and nephrotoxicity”. Derivatives of β-Cyclodextrin with improved water solubility (e.g. Hydroxypropyl-β-Cyclodextrin i.e HP-β-CYD) are most commonly pharmaceutical formulation.CYDs have been revealed to enhance the solubility of sparingly soluble drugs by making inclusion complexes. Among the a variety of customized β-cyclodextrins, hydroxypropyl-β-cyclodextrin (HP-β-CYD) and sulfoxybutyl ether-β-cyclodextrin are the negligible amount of toxic and may be useful in the improvement of parenteral dosage forms of these drugs.It is essential to use as small amount of CYDs as likely in pharmaceutical formulations. In this respect, aqueous solubility of α-CYD is more than β-CYD, taking extra advantages for this investigation (solubility in water (w/v) at 25 °C(298K): for α-CYD is 14.5 mg/ mL and β-CYD is 1.85 mg/ mL). 2-hydroxylpropyl-β-cyclodextrin (HP-β-CYD) is an substitute to α, β and γ-cyclodextrin, with enhanced water solubility and may be further toxicologically benign, mostly when dosed orally, and exhibits only narrow toxicity, formed extra slight haematological changes but no histopathological changes. Amongst these CYDs, β-CYD and its hydrophilic derivative, such as hydroxypropyl-β-cyclodextrins (HP-β-CYD) are the first choices because of their appropriate cavity sizes and modest cost. HP-β-CYD can be used in safety as a transporter for parenteral delivery of drugs. HP-β-CYD is not absorbed from the gastrointestinal tract. It is rapidly and almost entirely cleared from the systemic circulation by the kidneys after intravenous injection, and is cleared from the lung by being absorbed into the systemic circulation following administration in an aerosol. Amongst the three cyclodextrin homologues (α, β and γ) β-cyclodextrin is the slightest expensive. Undesirably, β-cyclodextrin has only a inadequate water solubility, and its complexes are consequently only a little water-soluble. Thus, β-cyclodextrin is frequently chemically customized to increase its water solubility. One of its derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CYD) was found to be extremely water-soluble. Hence, HP-β-CYD is used in this study. Newly, the anticancer consequence of HP- β - CYD has been revealed and proved in vivo in mouse model of leukemia.

Physicochemical approaches to inclusion complexes and different interactions

" Physicochemical approaches to inclusion complexes and different interactions", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.661-668, March-2020, Available :http://www.jetir.org/papers/JETIR2003402.pdf

" Physicochemical approaches to inclusion complexes and different interactions", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp661-668, March-2020, Available at : http://www.jetir.org/papers/JETIR2003402.pdf