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Published in:

Volume 7 Issue 5
May-2020
eISSN: 2349-5162

Unique Identifier

JETIR2005150

Page Number

56-63

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Title

Silymarin: Review on overall developed formulations and analytical methods

ISSN

2349-5162

Cite This Article

"Silymarin: Review on overall developed formulations and analytical methods", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 5, page no.56-63, May-2020, Available :http://www.jetir.org/papers/JETIR2005150.pdf

Abstract

Silymarin is flavonoid obtained from Silybum marianum plant. It is used as hepatoprotective, antioxidant, anti-inflammatory, hypolipidemic, and anti-carcinogenic properties[44]. Silymarin is BSC II class drug contains eight flavonolignans which having poor aqueous solubility due to this it rapidly excreted in bile and urine and poor bioavailability of these flavonolignans after oral route administration due to phase II metabolism, therefore in this review a potential approach to enhance solubility, bioavailability and to develop a robust formulation and scientific aspects from past to present is studied . In cancer treatment Nanomaterials are frequently used as drug carriers [12]. There is a need to have a selective and accurate analytical method for qualitative and quantitative estimation of silymarin flavonolignan elements[a]. Silymarin containing products have an important role in the quality control of milk thistle-based products. Due to the low concentrations of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques [N]. Therefore, the scope of this review was to develop a better understanding of the problems associated with silymarin and approaches to overcome the difficulties to develop a better and stable formulation for food and pharmaceutical applications.

Key Words

silymarin, hyphenated techniques, formulation, pharmacological activity.

Cite This Article

"Silymarin: Review on overall developed formulations and analytical methods", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp56-63, May-2020, Available at : http://www.jetir.org/papers/JETIR2005150.pdf

Publication Details

Published Paper ID: JETIR2005150
Registration ID: 231701
Published In: Volume 7 | Issue 5 | Year May-2020
DOI (Digital Object Identifier):
Page No: 56-63
ISSN Number: 2349-5162

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Cite This Article

"Silymarin: Review on overall developed formulations and analytical methods", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp56-63, May-2020, Available at : http://www.jetir.org/papers/JETIR2005150.pdf




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