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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

Unique Identifier

JETIR2006136

Page Number

977-982

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Title

FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF SIMVASTATIN

ISSN

2349-5162

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"FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF SIMVASTATIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.977-982, June-2020, Available :http://www.jetir.org/papers/JETIR2006136.pdf

Abstract

Simvastatin is a lipid lowering drug which is used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. Simvastatin is practically insoluble in water and undergoes extensive first-pass extraction in the liver. Thus the objective of the present research is to develop fast dissolving oral film of Simvastatin which avoid first pass metabolism and to have rapid onset of action. Oral films were prepared by solvent casting method using natural as well as synthetic film forming polymers like xanthan gum, guar gum, HPMC-K15 and HPMC-E15. The formulated films were evaluated for its appearance, thickness, uniformity in weight, surface pH, tensile strength, folding endurance, disintegration time and invitro dissolution rate. All films found to possess desirable physical and mechanical properties whereas the films based on HPMC K-15 and Xanthan gum (F2) as film former exhibited drug release of 99.42% in 18 minutes with satisfactory stability.

Key Words

Simvastatin, Fast Dissolving Oral Films, Solvent Casting method, HPMC

Cite This Article

"FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF SIMVASTATIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp977-982, June-2020, Available at : http://www.jetir.org/papers/JETIR2006136.pdf

Publication Details

Published Paper ID: JETIR2006136
Registration ID: 234087
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 977-982
ISSN Number: 2349-5162

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Cite This Article

"FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF SIMVASTATIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp977-982, June-2020, Available at : http://www.jetir.org/papers/JETIR2006136.pdf




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