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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

Unique Identifier

JETIR2006448

Page Number

790-795

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Title

Various Aspects of Laboratory Diagnosis of Tuberculosis on Multidrug Resistant Tuberculosis

ISSN

2349-5162

Cite This Article

"Various Aspects of Laboratory Diagnosis of Tuberculosis on Multidrug Resistant Tuberculosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.790-795, June-2020, Available :http://www.jetir.org/papers/JETIR2006448.pdf

Abstract

The latest WHO report estimates about 1.6 million global deaths annually from TB, which is further exacerbated by drugresistant (DR) TB and comorbidities with diabetes and HIV. Exiguous dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has resulted in an increased prevalence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and totally drugresistant TB (TDR-TB). Although a better understanding of the TB microanatomy, genome, transcriptome, proteome, and metabolome, has resulted in the discovery of a few novel promising anti-TB drug targets and diagnostic biomarkers of late, no new anti-TB drug candidates have been approved for routine therapy in over 50 years, with only bedaquiline, delamanid, and pretomanid recently receiving tentative regulatory approval. Considering this, alternative approaches for identifying possible new anti-TB drug candidates, for effectively eradicating both replicating and non-replicating Mycobacterium tuberculosis, are still urgently required. Subsequently, several antibiotic and non-antibiotic drugs with known treatment indications (TB targeted and non-TB targeted) are now being repurposed and/or derivatized as novel antibiotics for possible use in TB therapy.

Key Words

Adjunct drugs, Drug resistance, Monotherapy, Mycobacterium tuberculosis

Cite This Article

"Various Aspects of Laboratory Diagnosis of Tuberculosis on Multidrug Resistant Tuberculosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp790-795, June-2020, Available at : http://www.jetir.org/papers/JETIR2006448.pdf

Publication Details

Published Paper ID: JETIR2006448
Registration ID: 234700
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 790-795
ISSN Number: 2349-5162

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Cite This Article

"Various Aspects of Laboratory Diagnosis of Tuberculosis on Multidrug Resistant Tuberculosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp790-795, June-2020, Available at : http://www.jetir.org/papers/JETIR2006448.pdf




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