• Manoj Kumar
• Sangeeta Gehlot

ABSTRACT: Objective: Many herbal drugs are shifted from edge to main stream to use herbal remedies for the treatment of the disease with lesser side effects as compare to synthetic chemicals,in this chain Tephrosia purpurea (Sarapunkha) is one of the important drugs in Ayurvedic system of medicine. The present study was undertaken to find out the action of Tephrosia purpurea(Sarapunkha) on cardiovascular function. Administration of the preparations of Tephrosiapurpurea (Sarapunkha)in the clinical practice is done through oral route so that the active principles of the drug could reach the target organ like liver, kidney, spleen and heart. During the passage of the active principle, it is probable, that Tephrosia purpurea (Sarapunkha)ingredients might act on highly dynamic cardiovascular system. Method: Albino rats were used in this study ,Urethane (1.3 mg./gm. body weight) was selected for anaesthesia. The ECG recordings were taken, before and after-intra gastric administration of drug (0.5 mg./gm. body weight). Result: The study on Albino Rats shows that after feeding root powder decoction of Tephrosia purpurea (Sarapunkha), RR interval increased and thus heart rate was observed to decrease. Even though a decrease in force of contraction of the cardiac muscle under influence of Tephrosia purpurea(Sarapunkha) cannot be excluded. Conclusion: The Tephrosia purpurea (Sarapunkha) decoction preparation does influence the activity of the autonomic nervous system with consequent alterations in the functions of the cardio vascular system.

Key words: Albino rats, ECG, Sharapunkha,Tephrosia purpurea, Urethane.

"Systemic Effect of Sharapunkha on Cardio Vascular System: An Experimental Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 7, page no.163-168, July-2020, Available :http://www.jetir.org/papers/JETIR2007019.pdf

"Systemic Effect of Sharapunkha on Cardio Vascular System: An Experimental Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 7, page no. pp163-168, July-2020, Available at : http://www.jetir.org/papers/JETIR2007019.pdf