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Published in:

Volume 6 Issue 5
May-2019
eISSN: 2349-5162

Unique Identifier

JETIR2007049

Page Number

392-404

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Title

Studies on in-vitro dissolution enhancement of aceclofenac from oral solid dosage form using β & hp β -cyclodextrin complexes

ISSN

2349-5162

Cite This Article

"Studies on in-vitro dissolution enhancement of aceclofenac from oral solid dosage form using β & hp β -cyclodextrin complexes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.392-404, May-2019, Available :http://www.jetir.org/papers/JETIR2007049.pdf

Abstract

The solubility behaviour of drugs remains one of the most challenging aspects in formulation and development. The Complexation with cyclodextrins is very efficient technique for enhancement of solubility and used to improve the dissolution properties and bioavailability of poorly water soluble drugs. Today 40% of all new chemical entities suffer from poor aqueous solubility. It is generally recognized that low solubility or dissolution rate often become a rate limiting step in absorption of poorly water soluble drugs from gastro intestinal tract and compromise oral bioavailability. Aceclofenac was the drug candidate selected to improve its solubility and dissolution. An attempt was made to prepare complexation with β-CD and HP-β-CD. Complexes of β-CD and HP-β-CD in 1:1 molar ratios were prepared using three methods viz. kneading, solvent evaporation and microwave irradiation techniques. 1:1 (ACE: β-CD) complex tablet with kneading method showed more than 98% of drug release within 120 min in phosphate buffer pH 7.4 as dissolution medium. 1:1 (ACE:HP-β-CD) complex tablet with solvent evaporation method showed more than 95% of drug release within 120 min in phosphate buffer pH 7.4 as dissolution medium. 1:1 (ACE-β-CD) complex tablet with kneading method showed more than 81% of drug release within 120 min in 0.1N HCL pH 1.2 as dissolution medium. Release parameter t50% of developed and pure drug formulation indicated that the developed formulation has faster dissolution rate as compared to pure drug formulation

Key Words

Aceclofenac Cyclodextrin, dissolution, β & HP β –Cyclodextrin Complexes, solubility enhancement

Cite This Article

"Studies on in-vitro dissolution enhancement of aceclofenac from oral solid dosage form using β & hp β -cyclodextrin complexes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp392-404, May-2019, Available at : http://www.jetir.org/papers/JETIR2007049.pdf

Publication Details

Published Paper ID: JETIR2007049
Registration ID: 234990
Published In: Volume 6 | Issue 5 | Year May-2019
DOI (Digital Object Identifier):
Page No: 392-404
ISSN Number: 2349-5162

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Cite This Article

"Studies on in-vitro dissolution enhancement of aceclofenac from oral solid dosage form using β & hp β -cyclodextrin complexes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp392-404, May-2019, Available at : http://www.jetir.org/papers/JETIR2007049.pdf




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