• Ms. Sushal D. Pingale
• Dr. S. J. Kshirsagar
• Dr.Nilima A.Thombre
• Ms.Archana K.Gaikwad

Topical drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal, and skin as topical route. Skin is one of the most readily accessible organs on human body for topical administration and is main route of topical drug delivery system. Ketoconazole creams or ointments are used as antimicrobial agents in the treatment of skin infection. But application by touching the wounded surface is painful and may spread secondary infection. The objective of the present study was to formulate topical spray for wound healing to provide more patient compliance and reduce the chances of further contamination or spread of infection at the site of wound. Film forming preparations are defined as non-solid dosage forms that produce a substantial film in situ after application on the skin or any other body surface. Such compositions can either be liquids or semisolids with a film forming polymer as basic material for the matrix. The formed film is sufficiently substantial to provide a sustained drug release to the skin .An aqueous spray formulation of Ketoconazole was prepared using Eudragit E100 as film forming polymer and PG as plasticizer. The concentrations of polymer and plasticizer were optimized by 32 full factorial design, considering film forming time, volume per spray, area of film, % cumulative drug release as dependent factors (responses). The optimized batch with drying time in Sec and % drug release 93 ±1.4% in 150 min., showed comparable in-vivo antimicrobial activity with marketed formulation. Thus, a topical spray of Ketoconazole can be used for effective treatment of open wounds

Ketoconazol, Eudragit E100,PG, 32 factorial, Wound healing

"FORMULATION DEVELOPMENT AND EVALUATION OF FILM FORMING POLYMERIC SOLUTION OF ANTIFUNGAL ACTIVTY OF KETOCONAZOLE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.656-667, May-2019, Available :http://www.jetir.org/papers/JETIR2007080.pdf

"FORMULATION DEVELOPMENT AND EVALUATION OF FILM FORMING POLYMERIC SOLUTION OF ANTIFUNGAL ACTIVTY OF KETOCONAZOLE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp656-667, May-2019, Available at : http://www.jetir.org/papers/JETIR2007080.pdf