• Dr RAKESH R BABU
• Dr JAYAKRISHNAN P G

Visha(poison) is something which is toxic to bodies. The exposure to a toxic environment is unavoidable in the present era. Based on the origin of toxicity and its effect on the body, visha is divided into various types. Dooshivishas(cumulative toxins) are those toxic compounds which are not able to produce the acute symptoms and which partially undergoes biotransformation and accumulated in the body for long term producing various symptoms. The Liver, a primary site of metabolism, is the major organ affected by fat metabolism. The improper metabolism leads to fatty infiltration of the liver which later affects the normal functions leading to a metabolic rearrangement in the body. NAFLD(Non-alcoholic fatty liver disease) represents a spectrum of illness with stages of hepatic steatosis, steatohepatitis, fibrosis and cirrhosis. In NAFLD, due to chronic use of virudhaaharavihara(in-compatible food and regimens), dooshivisha vitiates dhatus(rasa raktamamsa and medas)(tissues of the body such as plasma, blood, muscle, fat)and due to kaphadoshaavarana, defective digestion (agnimandya) and defective metabolism (dhatwagnimandhya) occur. Agnimandhya reflects as bhootagnimandhya and dhatvagnimandya. When dhatvagnimandya occurs the mostly affected agni is medodhatvagni (defective metabolism of fat) as the nidanas (causes) are favourable for its dushti (vitiation) and due to kaphaavarana of dooshivisha. Medodhatvagnimandhya (defective metabolism of fat) leads to the formation of samamedas (fat globules). The samamedas (fat globules) reaches the yakrut (liver), sthanasamsraya occurs at yakrut (liver) and impairs the functions of yakrut (liver). The pathology of NAFLD coincides with that of dooshivisha.

Visha, Dooshivisha, NAFLD

"AN AGADATANTRA PERSPECTIVE OF NON- ALCOHOLIC FATTY LIVER DISEASE- A CRITICAL REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 7, page no.404-411, July-2020, Available :http://www.jetir.org/papers/JETIR2007349.pdf

"AN AGADATANTRA PERSPECTIVE OF NON- ALCOHOLIC FATTY LIVER DISEASE- A CRITICAL REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 7, page no. pp404-411, July-2020, Available at : http://www.jetir.org/papers/JETIR2007349.pdf