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Published in:

Volume 7 Issue 9
September-2020
eISSN: 2349-5162

Unique Identifier

JETIR2009053

Page Number

400-405

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Title

A GLANCE ON STRUCTURE AND ABNORMAL HYPERPHOSPHORYLATION OF TAU PROTEIN

ISSN

2349-5162

Cite This Article

"A GLANCE ON STRUCTURE AND ABNORMAL HYPERPHOSPHORYLATION OF TAU PROTEIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 9, page no.400-405, September-2020, Available :http://www.jetir.org/papers/JETIR2009053.pdf

Abstract

Microtubule related protein (MAP) tau is anomalous hyperphosphorylated in Alzheimer's malady (AD) and related tauopathies; in this structure it is the significant protein subunit of combined helical fibers (PHF)/neurofibrillary tangles. Tau protein plays a role in microtubule assembly and dynamics that may regulate neuron morphology. This gene is transcribed into a nuclear RNA that yields six different isoforms, lacking or containing exons 2, 3, and 10 by alternative splicing. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia and other tauopathies. Mechanisms involved in hyperphosphorylation of tau are reduced level of protein O-GlcNAcylation, which reciprocally regulates phosphorylation , reduced activity of PP-2A in AD brain, increase in the activities of CaMKII, PKA and MAP kinases, inherited FTDP-17, tau mutations G272V, P301L, V337M and R406W, alterations in PP2A and PP2A regulatory proteins.

Key Words

Tau, hyperphosphorylation, hexosamine, O-GlcNAcylation, CaMKII, PKA and MAP kinases, FTDP-17, PP2A and PP2A regulatory proteins.

Cite This Article

"A GLANCE ON STRUCTURE AND ABNORMAL HYPERPHOSPHORYLATION OF TAU PROTEIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 9, page no. pp400-405, September-2020, Available at : http://www.jetir.org/papers/JETIR2009053.pdf

Publication Details

Published Paper ID: JETIR2009053
Registration ID: 300662
Published In: Volume 7 | Issue 9 | Year September-2020
DOI (Digital Object Identifier):
Page No: 400-405
ISSN Number: 2349-5162

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Cite This Article

"A GLANCE ON STRUCTURE AND ABNORMAL HYPERPHOSPHORYLATION OF TAU PROTEIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 9, page no. pp400-405, September-2020, Available at : http://www.jetir.org/papers/JETIR2009053.pdf




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