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Published in:

Volume 7 Issue 10
October-2020
eISSN: 2349-5162

Unique Identifier

JETIR2010189

Page Number

1480-1489

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Title

Bacterial and Viral Pathogen Spectra of Acute Respiratory Infections in under-5 Children in Hospital Settings in Mymensingh Division

ISSN

2349-5162

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"Bacterial and Viral Pathogen Spectra of Acute Respiratory Infections in under-5 Children in Hospital Settings in Mymensingh Division", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 10, page no.1480-1489, October-2020, Available :http://www.jetir.org/papers/JETIR2010189.pdf

Abstract

The study aimed to examine for the first time the spectra of viral and bacterial pathogens along with the antibiotic susceptibility of the isolated bacteria in under-5 children with acute respiratory infections (ARIs) in hospital settings of Dhaka, Bangladesh. Nasal swabs were collected from 200 under-five children hospitalized with clinical signs of ARIs. Nasal swabs from 30 asymptomatic children were also collected. Screening of viral pathogens targeted ten respiratory viruses using RT-qPCR. Bacterial pathogens were identified by bacteriological culture methods and antimicrobial susceptibility of the isolates was determined following CLSI guidelines. About 82.5% (n = 165) of specimens were positive for pathogens. Of 165 infected cases, 3% (n = 6) had only single bacterial pathogens, whereas 43.5% (n = 87) cases had only single viral pathogens. The remaining 36% (n = 72) cases had confections. In symptomatic cases, human rhinovirus was detected as the predominant virus (31.5%), followed by RSV (31%), HMPV (13%), HBoV (11%), HPIV-3 (10.5%), and adenovirus (7%). Streptococcus pneumonia was the most frequently isolated bacterial pathogen (9%), whereas Klebsiella pneumonias, Streptococcus spp., Enterobacter agglomerans, and Homophiles influenza were 5.5%, 5%, 2%, and 1.5%, respectively. Of 15 multidrug-resistant bacteria, a Klebsiella pneumonia isolate and an Enterobacter agglomerans isolate exhibited resistance against more than 10 different antibiotics. Both ARI incidence and predominant pathogen detection rates were higher during post-monsoon and winter, peaking in September. Pathogen detection rates and confection incidence in less than 1-year group were significantly higher (P = 0.0034 and 0.049, respectively) than in 1–5 years age group. Pathogen detection rate (43%) in asymptomatic cases was significantly lower compared to symptomatic group (P<0.0001). Human rhinovirus, HPIV-3, adenovirus, Streptococcus pneumonia, and Klebsiella pneumonias had significant involvement in confections with P values of 0.0001, 0.009 and 0.0001, 0.0001 and 0.001 respectively. Further investigations are required to better understand the clinical roles of the isolated pathogens and their seasonality.

Key Words

Bacterial, Viral Pathogen, Respiratory, Infections

Cite This Article

"Bacterial and Viral Pathogen Spectra of Acute Respiratory Infections in under-5 Children in Hospital Settings in Mymensingh Division", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp1480-1489, October-2020, Available at : http://www.jetir.org/papers/JETIR2010189.pdf

Publication Details

Published Paper ID: JETIR2010189
Registration ID: 302233
Published In: Volume 7 | Issue 10 | Year October-2020
DOI (Digital Object Identifier):
Page No: 1480-1489
ISSN Number: 2349-5162

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Cite This Article

"Bacterial and Viral Pathogen Spectra of Acute Respiratory Infections in under-5 Children in Hospital Settings in Mymensingh Division", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp1480-1489, October-2020, Available at : http://www.jetir.org/papers/JETIR2010189.pdf




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