• MR. MODH NIRAV
• DR. MITTAL MAHESHWARI
• DR. PRAGNESH PATANI

ABSTRACT: Objective: The objective of the present investigation was to formulate and evaluate microencapsulated Glimepiride produced by the emulsion – solvent evaporation method. Methods: Microparticles were prepared using Cellulose Acetate by emulsion solvent evaporation method and characterized for their micromeritic properties, encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis. In vitro release studies were performed in phosphate buffer (pH 7.4). Stability studies were conducted as per ICH guidelines. Results: The resulting microparticles obtained by solvent evaporation method were free flowing in nature. The mean particle size of microparticles ranges from 145.26 – 187.42 µm and encapsulation efficiency ranges from 90.38 – 96.00%. The mean particle size of microparticles ranges from 140.49 - 189.71μm and encapsulation efficiency ranges from 91.60 - 96.24% The infrared spectra and differential scanning calorimetry thermographs confirmed the stable character of Glimepiride in the drug-loaded microparticles. Scanning electron microscopy revealed that the microparticles were spherical in nature. In vitro release studies revealed that the drug release was sustained up to 12 hrs. The release kinetics of Glimepiride from optimized formulation followed zero-order and papas’ mechanism. The mechanism of drug release from the microparticles was found to be non-Fiskian type. Conclusion: Eudragit RLPO microparticles containing Glimepiride could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner. Cellulose Acetate microparticles containing Glimepiride could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner.

Keywords: Glimepiride, Eudragit RLPO, Microparticles, Emulsion Solvent Evaporation, Controlled/Sustained Release, Microencapsulation, Diabetes Mellitus, Sulphonyl urea’s, Invitro Evaluation, Release kinetics.

"Formulation and Evaluation of Glimepiride Loaded Cellulose Acetate Microparticles Prepared by An Emulsion Solvent Evaporation Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.384-388, November-2020, Available :http://www.jetir.org/papers/JETIR2011052.pdf

"Formulation and Evaluation of Glimepiride Loaded Cellulose Acetate Microparticles Prepared by An Emulsion Solvent Evaporation Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp384-388, November-2020, Available at : http://www.jetir.org/papers/JETIR2011052.pdf