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Published in:

Volume 7 Issue 11
November-2020
eISSN: 2349-5162

Unique Identifier

JETIR2011179

Page Number

327-339

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Title

Formulation development and characterization of Chitosan nanoparticles bearing Rizatriptan Benzoate for intranasal delivery

ISSN

2349-5162

Cite This Article

"Formulation development and characterization of Chitosan nanoparticles bearing Rizatriptan Benzoate for intranasal delivery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.327-339, November-2020, Available :http://www.jetir.org/papers/JETIR2011179.pdf

Abstract

The present investigation was aimed to formulate and characterize chitosan nanoparticles (CS-NPs) loaded with Rizatriptan Benzoate (RIZ) for intranasal administration for brain targeting. The NPs were prepared using inotropic gelation method. Optimization of the process and formulation parameters was done using the Box-Behnken design (BBD). The optimized batch having the concentrations of chitosan and sodium tri-polyphosphate were found to be 0.4 %w/v and 0.3 %w/v respectively while the Zeta potential and Z-average size were also found to be +49 mV and 201 nm with poly dispersity index of 0.2 respectively. Drug entrapment efficiency (% EE) and drug loading (% DL) were of 63.5±1.61% and 17.3±1.38 % w/w respectively. Moreover, improved in-vitro and ex-vivo release profile of CS-NPs were observed in comparison to drug solution. In a nutshell, the developed formulation holds a great promise in overcoming the limitation associated with currently marketed RIZ formulations and illustrates the potential use of CS-NPs to administer the drug by nasal route for brain targeting.

Key Words

Chitosan nanoparticles (CS-NPs), Ionotropic gelation, Rizatriptan benzoate, Brain delivery, Migraine

Cite This Article

"Formulation development and characterization of Chitosan nanoparticles bearing Rizatriptan Benzoate for intranasal delivery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp327-339, November-2020, Available at : http://www.jetir.org/papers/JETIR2011179.pdf

Publication Details

Published Paper ID: JETIR2011179
Registration ID: 303524
Published In: Volume 7 | Issue 11 | Year November-2020
DOI (Digital Object Identifier):
Page No: 327-339
ISSN Number: 2349-5162

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Cite This Article

"Formulation development and characterization of Chitosan nanoparticles bearing Rizatriptan Benzoate for intranasal delivery", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp327-339, November-2020, Available at : http://www.jetir.org/papers/JETIR2011179.pdf




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