UGC Approved Journal no 63975(19)

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Published in:

Volume 8 Issue 1
January-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2101164


Registration ID:
305233

Page Number

1302-1321

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Title

Advancement of cytoprotection through suppression of p53 protein

Abstract

P53 proteins are the one the most important tumor suppressors which helps in modulating the fate and determination in relative for a variety of cellular regulations via cell apoptosis. Here the p53 suppression in the main protein which helps in cytoprotection, neuroprotection, hepatoprotection and radioprotection like actions which may be natural like curcumin, Bilobalide, silymarin, Andrographolide etc. whereas, synthetic suppressor of p53 protein are pifithrin-alfa, pifithrin-mu, amifostine, 8-hydroxyquinoline, salidroside etc. In cytoprotectives the cellular targeting would induce the p53 tumor suppressor which induces differentiating cells restriction or cell death. The neuroprotective agents act via neuro inflammation, oxidative stress, autophagy, reactive oxygen units, and cell death signal cascade, which will occur instant when cell proliferationis acute, pro-apoptotic factors like Bax, caspase-3, Nuclear regions and p53; initiates the mechanism of neuronal apoptosis. The radioprotection and hepatoprotection occurs via the mechanism of down-regulating pro apoptotic factors like; Alpaf 1, Noxa and Bax., where in hepatoprotection the livers cell death and rupture, p53-down regulated the liver lethality, and therefore p53 is a protective agent that would protect hepatic rupture via apoptosis. The recent advancements via p53 suppression leading to various apoptotic factors is a great discovery for the various cytoprotectives, radioprotective, hepatoprotective and neuroprotection actions.

Key Words

p53 protein suppression, Natural Products, Apoptosis, Down-regulation, Radioprotection, Hepatoprotection, Neuroprotection, Cytoprotection.

Cite This Article

"Advancement of cytoprotection through suppression of p53 protein", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 1, page no.1302-1321, January-2021, Available :http://www.jetir.org/papers/JETIR2101164.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Advancement of cytoprotection through suppression of p53 protein", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 1, page no. pp1302-1321, January-2021, Available at : http://www.jetir.org/papers/JETIR2101164.pdf

Publication Details

Published Paper ID: JETIR2101164
Registration ID: 305233
Published In: Volume 8 | Issue 1 | Year January-2021
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.25547
Page No: 1302-1321
Country: Jalpaiguri, West Bengal, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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