UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
Call for Paper
Volume 11 | Issue 3 | March 2024

JETIREXPLORE- Search Thousands of research papers



WhatsApp Contact
Click Here

Published in:

Volume 8 Issue 2
February-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

Unique Identifier

Published Paper ID:
JETIR2102050


Registration ID:
305571

Page Number

456-464

Share This Article


Jetir RMS

Title

DEVELOPMENT AND EVALUATION OF NICOTINAMIDE AND SACCHARIN GLIBENCLAMIDE CO-CRYSTAL MOUTH DISSOLVING TABLET

Abstract

The aim of present work was to prepare glibenclamide (GBC) co-crystal using co-crystallization approach with an objective to improve solubility study and dissolution rate of formulation. Co-crystallization of GBC was prepared by using solvent evaporation technique with the help of coformer i.e. nicotinamide and sodium saccharin co-crystal. The prepared co-crystal were characterized for melting point, solubility, micromeritics properties, FTIR, XRD, DSC and SEM. Various batches of tablet (F1-F4) were successfully prepared using GBC nicotinamide and saccharin co-crystal, further was evaluate for physical properties, disintegration time and drug release and compared with powder GBC co-crystal and pure GBC (F5 – F6). Ethanol solubility study of pure GBC (4.021 µg/ml) and its co-crystal result reveals that solubility of GBC co- crystal with nicotinamide (39.27µg/ml) is 8-9 fold higher than pure GBC. Microscopic analysis of crystal revealed visual difference between the co-crystal and pure GBC. DSC data of co-crystal shows difference in melting point which confirms formation of stable crystal. Disintegration and dissolution study for all the formulation indicate that F1 showed rapid disintegration (56 sec) and drug release of 100% in 8 min. Based on melting point, solubility study, micromeritics properties, FTIR, XRD, DSC, SEM, disintegration and drug release study it can be concluded that the mouth dissolving tablet of GBC nicotinamide and saccharin co-crystal can be successfully prepared with significantly enhanced solubility, rapid disintegration and

Key Words

Glibenclamide (GBC), nicotinamide, saccharin, co-crystal, Co-crystallization, Mouth Dissolving Tablet.

Cite This Article

"DEVELOPMENT AND EVALUATION OF NICOTINAMIDE AND SACCHARIN GLIBENCLAMIDE CO-CRYSTAL MOUTH DISSOLVING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 2, page no.456-464, February-2021, Available :http://www.jetir.org/papers/JETIR2102050.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"DEVELOPMENT AND EVALUATION OF NICOTINAMIDE AND SACCHARIN GLIBENCLAMIDE CO-CRYSTAL MOUTH DISSOLVING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 2, page no. pp456-464, February-2021, Available at : http://www.jetir.org/papers/JETIR2102050.pdf

Publication Details

Published Paper ID: JETIR2102050
Registration ID: 305571
Published In: Volume 8 | Issue 2 | Year February-2021
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.25738
Page No: 456-464
Country: Ahmednagar, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


Preview This Article


Downlaod

Click here for Article Preview

Download PDF

Downloads

0003146

Print This Page

Current Call For Paper

Jetir RMS