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"DEVELOPMENT AND EVALUATION OF NICOTINAMIDE AND SACCHARIN GLIBENCLAMIDE CO-CRYSTAL MOUTH DISSOLVING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 2, page no.456-464, February-2021, Available :http://www.jetir.org/papers/JETIR2102050.pdf

• Ambekar Abdul Wahid Abdul Aziz
• Rohini Chavan
• Sable Ankita

The aim of present work was to prepare glibenclamide (GBC) co-crystal using co-crystallization approach with an objective to improve solubility study and dissolution rate of formulation. Co-crystallization of GBC was prepared by using solvent evaporation technique with the help of coformer i.e. nicotinamide and sodium saccharin co-crystal. The prepared co-crystal were characterized for melting point, solubility, micromeritics properties, FTIR, XRD, DSC and SEM. Various batches of tablet (F1-F4) were successfully prepared using GBC nicotinamide and saccharin co-crystal, further was evaluate for physical properties, disintegration time and drug release and compared with powder GBC co-crystal and pure GBC (F5 – F6). Ethanol solubility study of pure GBC (4.021 µg/ml) and its co-crystal result reveals that solubility of GBC co- crystal with nicotinamide (39.27µg/ml) is 8-9 fold higher than pure GBC. Microscopic analysis of crystal revealed visual difference between the co-crystal and pure GBC. DSC data of co-crystal shows difference in melting point which confirms formation of stable crystal. Disintegration and dissolution study for all the formulation indicate that F1 showed rapid disintegration (56 sec) and drug release of 100% in 8 min. Based on melting point, solubility study, micromeritics properties, FTIR, XRD, DSC, SEM, disintegration and drug release study it can be concluded that the mouth dissolving tablet of GBC nicotinamide and saccharin co-crystal can be successfully prepared with significantly enhanced solubility, rapid disintegration and

Glibenclamide (GBC), nicotinamide, saccharin, co-crystal, Co-crystallization, Mouth Dissolving Tablet.

"DEVELOPMENT AND EVALUATION OF NICOTINAMIDE AND SACCHARIN GLIBENCLAMIDE CO-CRYSTAL MOUTH DISSOLVING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 2, page no. pp456-464, February-2021, Available at : http://www.jetir.org/papers/JETIR2102050.pdf