• Gaganpreet Kaur Lally
• Sourav Patil
• Savikaran Boparia
• Varinder Pal Singh
• Antarpreet Kaur

Respiratory diseases are those which are related to airways and lung disorders. Nrf2 (67kDa pzip CNC transcription factor) nuclear erythroid 2-related factor is a transcription factor with complex multi- domain proteins which regulates the anti-oxidant response element (ARE) driven cyto protective protein expression. It is believed that Nrf2 activation reduces the systemic inflammation, lowers the oxidative stress and improves the mitochondrial function and this can be useful in treating various respiratory diseases like chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis(IPF), bronchopulmonary dysplasia (BPD), asthma, infection related to respiratory organs, acute respiratory distress syndrome(ARDS), lung cancer etc. Nrf2 activation helps to prevent the tissue or cell damage occurred by oxidative stress. under stress, kelch like ECH associated protein (cysteine rich protein), a natural inhibitor of Nrf2, traps Nrf2 in cytoplasm thus degrades Nrf2 by 26s proteosome. stress impairs the protein to target Nrf2 for ubiquitination, degrade and uses Nrf2 (newly synthesized) to translocate to nucleus and bind with ARE. These activators can be activated by exercise, fasting or by restriction calories or also by intake of natural nutrients. Nrf2 activators used commonly are Curcumin (lung cancer), anti-oxidants found in green tea, Resveratrol(Pneumococcal infections, ARDS,COPD, Lung cancer), vitamin E (Asthma), Sulforaphane (Asthma,IPF, lung cancer), Emodin (IPF, IAV infections), Quercetin (IPF), derivative BHBA(lung cancer), Cinnamaldehyde, Bixin,tBHQ (RSV infection, ARDS) etc.

Nrf activator, Respiratory diseases, Sulforaphane, Asthma, COPD

"The Role of Natural Nrf Activators in Respiratory Diseases", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 2, page no.837-845, February-2021, Available :http://www.jetir.org/papers/JETIR2102098.pdf

"The Role of Natural Nrf Activators in Respiratory Diseases", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 2, page no. pp837-845, February-2021, Available at : http://www.jetir.org/papers/JETIR2102098.pdf