JETIREXPLORE- Search Thousands of research papers



Published in:

Volume 8 Issue 3
March-2021
eISSN: 2349-5162

Unique Identifier

JETIR2103019

Page Number

147-154

Share This Article


Title

MOLECULAR DOCKING APPROACH ON CAPSAICIN TO REGULATE BRAIN CHOLESTEROL AN INSILICO STUDY

ISSN

2349-5162

Cite This Article

"MOLECULAR DOCKING APPROACH ON CAPSAICIN TO REGULATE BRAIN CHOLESTEROL AN INSILICO STUDY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 3, page no.147-154, March-2021, Available :http://www.jetir.org/papers/JETIR2103019.pdf

Abstract

ABSTRACT: Red Chilli (Capsicum annum) is important as a spice, flavour enhancer, vegetable and component in herbal medicine. The numerous phytochemicals and their medicinally important properties present in diverse germplasm of chilli pepper have been characterized and documented. Capsaicinoids, carotenoids, vitamins, flavonoids such as anthocyanins are present as the major phytochemicals in chilli pepper fruits. Capsaicinoids, pungent analogues of capsinoids, are the most important group of phytochemicals in which capsaicin and dihydrocapsaicin are prominent in providing the basis for pungency and medicinal properties. This study analysed Molecular docking of Pubchem retrieved 2D structures of selected phytocompounds present in Capsicum annum with 3D crystal structure of Cholesterol 24-hydroxylase protein retrieved from PDB. The human brain accounts for 2% of the whole body mass, yet it contains approximately 25% of the total cholesterol of the body. Cholesterol is a major lipid constituent of the myelin sheath and the membrane lipid rafts in neurons and astrocytes. It has an important role in brain development and neuronal function by regulating cell signaling pathways, gene transcription, and avail- ability of bioactive steroids. Cholesterol synthesis and metabolism in the brain involve complex interactions between astrocytes and neurons. Abnormalities in cholesterol metabolism in the CNS occur in several neurologic disorders, including Niemann-Pick type C and Smith-Lemli-Opitz syndrome. Brain cholesterol has also been implicated in the pathogenesis of Alzheimer disease (AD) and Hun-tington disease. The Docking was done by schrodinger Maestero 12.1 software tool, Capsaicin compound of Capsicum annum having best binding score than the other compounds present in it. Hence it has been concluded Capsaicin can be used in regulation of Brain Cholesterol.

Key Words

KEYWORDS: Capsicum annum, Capsaicin, Cholesterol 24-hydroxylase, Brain Cholesterol, Maestero 12.1, Glide.

Cite This Article

"MOLECULAR DOCKING APPROACH ON CAPSAICIN TO REGULATE BRAIN CHOLESTEROL AN INSILICO STUDY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 3, page no. pp147-154, March-2021, Available at : http://www.jetir.org/papers/JETIR2103019.pdf

Publication Details

Published Paper ID: JETIR2103019
Registration ID: 306376
Published In: Volume 8 | Issue 3 | Year March-2021
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.26071
Page No: 147-154
ISSN Number: 2349-5162

Download Paper

Preview Article

Download Paper




Cite This Article

"MOLECULAR DOCKING APPROACH ON CAPSAICIN TO REGULATE BRAIN CHOLESTEROL AN INSILICO STUDY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 3, page no. pp147-154, March-2021, Available at : http://www.jetir.org/papers/JETIR2103019.pdf




Preview This Article


Downlaod

Click here for Article Preview