• Aman Mittal
• Aasif
• Dipti Khairiya
• Tanushi Chauhan

Intra-periodontal pocket, mucoadhesive drug delivery systems have been shown to be clinically effective in the treatment of periodontitis. The aim of this study was to formulate a mucoadhesive gel from the fruits of Coriander sativum for the treatment of periodontitis. Coriander (Coriandrum sativum) fruit from umbeliferae family is an annual herb originates in India, used as medicine in disorder of digestive, respiratory and urinary system, as it has diuretic, carminative and stimulant activity. Pharmacological studies have demonstrated the hypoglycaemic, hypolipidemic, antimutagenic, antihypertensive, antioxidant, antimicrobial and postcoital antifertility activity of Coriander sativum. The semisolid concentrated extracts were incorporated in gel base. Mucoadhesive gel was prepared by using Carbopol 940, sodium CMC and HPMC as bio adhesive polymer. Physiochemical tests, mucoadhesive strength measurement and in-vitro drug release study were carried out on all formulations (F1-F5) containing Carbopol 940 sodium CMC polymers. Mucoadhesion and viscosity of F5 were good.

coriander, mucoadhesive gel, periodontitis, HPMC, Carbopol

"Formulation & Evaluation of Mucoadhesive Gel of Coriandrum sativum Fruit Extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 3, page no.547-559, March-2021, Available :http://www.jetir.org/papers/JETIR2103076.pdf

"Formulation & Evaluation of Mucoadhesive Gel of Coriandrum sativum Fruit Extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 3, page no. pp547-559, March-2021, Available at : http://www.jetir.org/papers/JETIR2103076.pdf