UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 5 Issue 7
July-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRA006014


Registration ID:
185394

Page Number

71-77

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Title

FORMULATION AND EVALUATION OF MODIFIED RELEASE MATRIX TABLET OF A MODEL ANTIBIOTIC

Abstract

The purpose of the investigation was Formulation and Evaluation of Modified release matrix tablet of Model antibiotic, for which Bioequivalence will be proved with reference product and a better bioavailability, may be expected than reference product. Drug polymer compatibility was studied by Physical observation and FTIR study. The drug and polymer in the optimized formulation was found to be compatible. Model tablet was prepared by Direct compression method.750mg of Model drug was taken in a single tablet of 1200mg.The evaluation parameter such as Weight variation, Thickness, Hardness, Friability, Drug content uniformity, In-vitro drug release studies in different dissolution medias i.e., 0.1 N HCL, 0.01 N HCL,4.5 AB,6.8 PB, stability testing of matrix tablets using ICH accelerated stability conditions were performed. The results were within the limit. From the release profile, F7 was selected to be the best formulation as it showed complete and most comparable release with respect to reference product. The order of release was zero order, mechanism of release was diffusion controlled and exponent of release was Non- fickian type diffusion controlled.

Key Words

Modified release, Matrix tablet, Antibiotic, Non-fickian

Cite This Article

"FORMULATION AND EVALUATION OF MODIFIED RELEASE MATRIX TABLET OF A MODEL ANTIBIOTIC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.71-77, July-2018, Available :http://www.jetir.org/papers/JETIRA006014.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF MODIFIED RELEASE MATRIX TABLET OF A MODEL ANTIBIOTIC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp71-77, July-2018, Available at : http://www.jetir.org/papers/JETIRA006014.pdf

Publication Details

Published Paper ID: JETIRA006014
Registration ID: 185394
Published In: Volume 5 | Issue 7 | Year July-2018
DOI (Digital Object Identifier):
Page No: 71-77
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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