• Dr.T.Sakthika
• Dr.A.S.Santhalakshmi

The aim of this experiment was to investigate the effect of sodium fluoride (NaF) on bilirubin, liver enzymes (SGPT and SGOT) and liver morphology and its amelioration by Probitic bacteria Lactobacillus rhamnosus. Twelve weeks old, albino rats (Rattus norvegicus) with average weight of 120g were randomly distributed into three groups of four animals each. The first group was kept as control. The second group was given 5ml drinking water with 0.151mg NaF /kg- bw/day and the third group was fed the same dose of NaF and 5ml water with Probitic bacteria Lactobacillus rhamnosus. After 60 days of experimental period Bilirubin, SGOT and SGPT were significantly (P<0.01) increased in the NaF treated rat. Histological examination of the liver revealed focal necrosis, liver congestion and vacuolar degeneration. However, rats treated with Lactobacillus rhamnosus showed significant improvement in all these three parameters and in the liver morphology. From the study, it could be concluded that fluoridated water caused liver damage and these effects could be ameliorated by Lactobacillus rhamnosus.

Rat, NaF, Liver Toxicity, Lactobacillus rhamnosus, Amelioration.

"AMELIORATION OF FLUORIDE INDUCED HEPATOTOXICITY IN ALBINO RAT BY PROBITIC BACTERIA LACTOBACILLUS RHAMNOSUS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.976-985, February-2019, Available :http://www.jetir.org/papers/JETIRAB06183.pdf

"AMELIORATION OF FLUORIDE INDUCED HEPATOTOXICITY IN ALBINO RAT BY PROBITIC BACTERIA LACTOBACILLUS RHAMNOSUS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp976-985, February-2019, Available at : http://www.jetir.org/papers/JETIRAB06183.pdf