• Shadab A Siddiqui
• Kiran Sharma
• Vandana Handa
• Parul Grover

Chronotherapeutics is the discipline concerned with the delivery of drugs according to the intrinsic activities of a disease over a certain period of time, on the basis of the observation that there is an interdependent relationship between peak-to-trough rhythmic activity in disease symptoms and risk factors, pharmacologic sensitivity and pharmacokinetics of many drugs. As the effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr rhythms of biochemical, physiological, pathological and behavioral processes under the control of circadian clock. If symptoms of a disease display circadian variation, drug release should also vary over time to match the circadian rhythms of the disease. The specific time at which the patients take their medication is very important as it has significant impact on the success of treatment as the optimum clinical outcome cannot be achieved if drug plasma concentrations are constant. For the successful treatment the drug should be delivered at the right site of action at the right time and in the right amount, thus providing minimal side effects with optimum therapeutic effect and increased patient compliance. Thus the time programmed release delivery systems can prove more beneficial than the conventional systems in the era of modern therapies for the patient. Rather than searching the new drugs for the treatment, release modified systems can save much more time of drug discovery process.

Chronotherapeutics; circadian rhythm; chronopharmacology; chronopharmacokinetics; drug delivery systems;

"Chronotherapeutic Drug Delivery Systems: An approach to synchronize drug concentrations to circadian rhythms in disease state.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.131-135, June 2019, Available :http://www.jetir.org/papers/JETIRDH06020.pdf

"Chronotherapeutic Drug Delivery Systems: An approach to synchronize drug concentrations to circadian rhythms in disease state.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp131-135, June 2019, Available at : http://www.jetir.org/papers/JETIRDH06020.pdf