• CHHAYA D. BADNAKHE
• P. R. RAJPUT
• ASHISH V. GAJBHIYE

The synthesis, spectral analysis and biological activities of 4-phenyl-2-hydroxy-chlorosubstituted-2-imino-1,3 thiazines have been carried out. In this case 4-(2'-hydroxy-3',5'-dichlorophenyl)-6-(4"-nitrophenyl)-2- iminophenyl-3,6-dihydro-1,3-thiazine (B), and has been screened. The compound B was synthesized from 2'-hydroxy-3,5-dichlorophenyl-4-(4”-nitrophenyl) chalcone (a) by the action of phenylthiourea. The compound (a) was synthesized from 2’-hydroxy-3’,5’-dichloroacetophenone by the action of p-nitrobenzaldehyde in ethanol and 40% NaOH. The nanoparticles of the compound B has been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activities against some Gram positive Staphylococcus aureus and Streptococcus sp. and Gram negative Pseudomonas sp. and Solmonella typhi pathogens. All the newly synthesized compounds were found to be active against test pathogens.

Chalcone, thiazine, , phenylthiourea, antibacterial assay.

"SYNTHESIS AND ANTIBACTERIAL ASSAY OF SOME OF SUBSTITUTED 1,3-THIAZINES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.704-708, February 2020, Available :http://www.jetir.org/papers/JETIRDI06137.pdf

"SYNTHESIS AND ANTIBACTERIAL ASSAY OF SOME OF SUBSTITUTED 1,3-THIAZINES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp704-708, February 2020, Available at : http://www.jetir.org/papers/JETIRDI06137.pdf