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Published in:

Volume 7 Issue 3
March-2020
eISSN: 2349-5162

Unique Identifier

JETIRDN06013

Page Number

51-64

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Title

DEVELOPMENT AND CHARACTERIZATION OF TAMARINDUS INDICA-PHOSPOLIPIDS COMPLEX AS AN EFFECTIVE PHYTOCONSTITUENTS DELIVERY SYSTEM BY QbD APPROACH

ISSN

2349-5162

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"DEVELOPMENT AND CHARACTERIZATION OF TAMARINDUS INDICA-PHOSPOLIPIDS COMPLEX AS AN EFFECTIVE PHYTOCONSTITUENTS DELIVERY SYSTEM BY QbD APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.51-64, March-2020, Available :http://www.jetir.org/papers/JETIRDN06013.pdf

Abstract

The aim of the present study is to develop a complex of standardized Tamarindus indica (STI) and phospolipid with a goal to improve the bioavailability of its phytoconstituents. Tamarind is a flavonoid, glycoside that possesses different therapeutic activity.The poor solubility and dissolution rate limit its oral absorption and bioavailability. The phospholipid-STI complex was prepared using solvent evaporation method and characterized by various parameters like Solubility studies, Particle size determination, Infrared absorption (FTIR), Scanning electron microscopy (SEM), Entrapment efficiency etc. SEM reveal the reduction in crystallinity of extract in the complex. FTIR confirm the formation of phytophospholipid complex. The in vitro dissolution studies revealed a significantly higher efficiency of complex in releasing the STI in comparison to the pure STI, or the physical mixture. Phospholipid complex of STI may be of potential use in increasing the permeability and hence the bioavailability of tamarind. The result of the study revealed that the phospholipid complex may be considered as a promising drug delivery system that improves the absorption and bioavailability of plant constituents.

Key Words

Tamarindus Indica, Phospholipid Complex,Phytosomes, Qbd Approach.

Cite This Article

"DEVELOPMENT AND CHARACTERIZATION OF TAMARINDUS INDICA-PHOSPOLIPIDS COMPLEX AS AN EFFECTIVE PHYTOCONSTITUENTS DELIVERY SYSTEM BY QbD APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp51-64, March-2020, Available at : http://www.jetir.org/papers/JETIRDN06013.pdf

Publication Details

Published Paper ID: JETIRDN06013
Registration ID: 229530
Published In: Volume 7 | Issue 3 | Year March-2020
DOI (Digital Object Identifier):
Page No: 51-64
ISSN Number: 2349-5162

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Cite This Article

"DEVELOPMENT AND CHARACTERIZATION OF TAMARINDUS INDICA-PHOSPOLIPIDS COMPLEX AS AN EFFECTIVE PHYTOCONSTITUENTS DELIVERY SYSTEM BY QbD APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp51-64, March-2020, Available at : http://www.jetir.org/papers/JETIRDN06013.pdf




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