• Dr. Sachin U Kalme

A series of new N-substituted Ciprofloxacin derivatives were designed and synthesized. Their antibacterial activities were determined against Gram-negative microorganism. Specifically, N-substituted in a fluoroquinolone moiety (FQ) connected by various linker was synthesized according to their structure activity relationship studies. Selected N-substituted Ciprofloxacin derivatives showed DNA gyrase inhabitation compared to that Ciprofloxacin. We described a new 18F-labeled N-substituted Ciprofloxacin derivative ([18F] 6) which gives a specific activity compared to Ciprofloxacin and it was produced easily with high radiochemical yield using tertiary alcohol as a reaction media for nucleophilic fluorination. ([18F] 6) is applicable properties for future imaging of bacterial infection with PET.

Ciprofloxacin, Fluoroquinolene, Radiofluorination, Fluorine-18, Positron emission tomography (PET).

"Fluoroquinolone derivatives: New N-substituted Ciprofloxacin derivatives synthesis and evaluation of a specific 18F- Radiolabelled compound for PET Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.224-227, March-2020, Available :http://www.jetir.org/papers/JETIRDN06052.pdf

"Fluoroquinolone derivatives: New N-substituted Ciprofloxacin derivatives synthesis and evaluation of a specific 18F- Radiolabelled compound for PET Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp224-227, March-2020, Available at : http://www.jetir.org/papers/JETIRDN06052.pdf