• Pranav Kumar Prabhakar

Diabetes mellitus is one of such problems with multiple etiologies and serious life threatening co morbid complications. Diabetic nephropathy is the most serious secondary complication of DM with high rate of mortality and is the main cause of ESRD in adults. About 30% of diabetic patient (either type 1 or type 2) develops diabetic nephropathy and in the case of poor control of blood pressure and urinary albumin excretion, they lead to ESRD about 80% of which have hypertension which contributes in worsening of renal disease. In constant high glucose concentration, there is overproduction of mitochondrial superoxide which is blame to be responsible for the hyperglycemia induced apoptosis. Diabetic glumerulosclerosis is characterized by nodular lesions that consist of mesangial expansion that makes fibrilar mesangial zones, where the mesangial nuclei accumulate around nodules and compress the glomerular capillaries. The diabetic nephropathy pathology ultimately affect almost all the organs through different mechanism and hence it need to be understand and these information can be used for the development of advanced therapeutic strategy.

diabetes; nephropathy; free radicals; renal; etiology; capillaries

"Pathophysiology of Diabetic Nephropathy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.1451-1462, January 2019, Available :http://www.jetir.org/papers/JETIRDY06231.pdf

"Pathophysiology of Diabetic Nephropathy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp1451-1462, January 2019, Available at : http://www.jetir.org/papers/JETIRDY06231.pdf