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Published in:

Volume 5 Issue 12
December-2018
eISSN: 2349-5162

Unique Identifier

JETIREB06050

Page Number

435-450

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Title

Current Status Of Analytical Techniques Used For The Analsis Of Berberine And Its Salts

ISSN

2349-5162

Cite This Article

"Current Status Of Analytical Techniques Used For The Analsis Of Berberine And Its Salts", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.435-450, December 2018, Available :http://www.jetir.org/papers/JETIREB06050.pdf

Abstract

Berberine is a natural alkaloid obtained from different species of Berberis like Berberis aristata, vulgaris, aquifolum and so on having family berbediaceae. It is also called barberry. It has multispectral uses but its less oral bioavailability (<1%) limits its use. The water solubility of berberine is 0.000354mg/ml that can be increased by addition of salts like hydrochloride, fumarate, citrate etc. The melting point of Berberine is 193-196 º C and molecular weight is 372.5g/mol. It is used in the treatment of various diseases like diabetes, cancer, antimicrobial, anti-inflammatory, antiprotozoal and so on. Berberine is available in different dosage forms like tablets, beads, topicals gels and hydrogels pellets and various vesicular delivery systems. The log P, tPSA, %HSA of berberine was found to be −1.5, 40.9 A &25.98%, that means berberine is hydrophilic in nature. Berberine is mainly checked by HPLC, IR/HPLC-UV, HPLC and micro dialysis, CE/ESI-MS, Surface enhanced Raman scattering (SERS), UPLC/MS-MS, HPLC/ESI-MS, HPTLC, HPLC-UV etc. It is mostly analyzed by HPLC and Mass spectrometer. In current we are going to discuss about the Berberine, pharmacokinetic properties, physicochemical properties, uses of berberine, different available dosage forms and the analytical methods used to analyze berberine and its salts.

Key Words

Berberine, Antimicrobial, Hydrogels pellets, Surface enhanced Raman scattering, Mass spectrometer

Cite This Article

"Current Status Of Analytical Techniques Used For The Analsis Of Berberine And Its Salts", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp435-450, December 2018, Available at : http://www.jetir.org/papers/JETIREB06050.pdf

Publication Details

Published Paper ID: JETIREB06050
Registration ID: 233646
Published In: Volume 5 | Issue 12 | Year December-2018
DOI (Digital Object Identifier):
Page No: 435-450
ISSN Number: 2349-5162

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Cite This Article

"Current Status Of Analytical Techniques Used For The Analsis Of Berberine And Its Salts", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp435-450, December 2018, Available at : http://www.jetir.org/papers/JETIREB06050.pdf




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