• Mohit Sharda
• Bhupinder Kapoor
• Reena Gupta
• Mukta Gupta

Rheumatoid arthritis (RA) is an autoimmune disorder of joints that is one of major problem among the various orthopaedic problems. Various medications used for the treatment of RA includes non-steroidal anti-inflammatory drugs (NSAIDs), disease modifying anti-rheumatic drugs (DMARDs), steroids and biological products. Methotrexate is used as first line drug for the treatment of RA, either as monotherapy or in combination with NSAID’s or steroids. Conventional preparations of methotrexate like tablets, capsules and injections are currently available in the market. Novel drug delivery systems exhibit numerous advantages over the conventional formulations. Liposome, dendrimers, hydrogels and nanoparticles are the main technologies that are used for making targeted preparations. Other approaches like carriers substance like albumin, erythrocytes and gold shells are also used now a days to give direct effect on the target site. Side effects are very less with these preparations as distribution in organs other than target organs does not occur. These formulations will definitely prove to be a very effective and superior approach in treatment of rheumatoid arthritis.

Methotrexate, Rheumatoid arthritis, Liposomes, Novel drug delivery systems

"Novel Drug Delivery Systems of Methotrexate for Treatment of Rheumatoid Arthritis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.585-597, December 2018, Available :http://www.jetir.org/papers/JETIREB06074.pdf

"Novel Drug Delivery Systems of Methotrexate for Treatment of Rheumatoid Arthritis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp585-597, December 2018, Available at : http://www.jetir.org/papers/JETIREB06074.pdf