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Published in:

Volume 5 Issue 12
December-2018
eISSN: 2349-5162

Unique Identifier

JETIREB06148

Page Number

1229-1244

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Title

FORMULATION AND EVALUATION OF MIXED HYDROTROPIC SOLID DISPERSION OF HYDROCHLORTHIAZIDE

ISSN

2349-5162

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"FORMULATION AND EVALUATION OF MIXED HYDROTROPIC SOLID DISPERSION OF HYDROCHLORTHIAZIDE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.1229-1244, December 2018, Available :http://www.jetir.org/papers/JETIREB06148.pdf

Abstract

For increasing the therapeutic effectiveness of drugs having dissolution rate limited absorption improvement in their water solubility is essential. In the present work mixed hydrotropic solid dispersion of very slightly water soluble drug Hydrochlorthiazide was prepared in order to enhance its solubility. Sodium citrate, niacinamide and polyethylene glycol 4000 were used in different proportions for the preparation of mixed hydrotropic solid dispersion of Hydrochlorthiazide. The Highest solubility enhancement ratio was obtained when Hydrochlorthiazide was mixed with 1:1:1 blend of sodium citrate, niacinamide and polyethylene glycol 4000. For that reason solid dispersion prepared using 1:1:1 blend of sodium citrate, niacinamide and polyethylene glycol 4000 was used for scanning electron microscopy, in vitro dissolution study, differential scanning calorimetry and X ray diffraction analysis. Mixed hydrotropic solid dispersions were tested for stability according to ICH guidelines. Rough, disordered and intact structures of solid dispersion might be helpful for increasing the dissolution of Hydrochlorthiazide when come in contact aqueous fluid. Crystalline nature of Hydrochlorthiazide was confirmed through the sharp and intense peaks of Hydrochlorthiazide on XRD. Differential scanning calorimetry graphs indicated complete dispersion of Hydrochlorthiazide in the mixture of hydrotropic solvents. Solid dispersions were found to be effective in releasing Hydrochlorthiazide at higher rate in comparison to pure Hydrochlorthiazie and physical mixture of Hydrochlorthiazide. All formulations were found to be chemically stable at higher temperature

Key Words

Hydrotropic solubilization, Hydrochlorthiazide, solid dispersion

Cite This Article

"FORMULATION AND EVALUATION OF MIXED HYDROTROPIC SOLID DISPERSION OF HYDROCHLORTHIAZIDE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp1229-1244, December 2018, Available at : http://www.jetir.org/papers/JETIREB06148.pdf

Publication Details

Published Paper ID: JETIREB06148
Registration ID: 233842
Published In: Volume 5 | Issue 12 | Year December-2018
DOI (Digital Object Identifier):
Page No: 1229-1244
ISSN Number: 2349-5162

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Cite This Article

"FORMULATION AND EVALUATION OF MIXED HYDROTROPIC SOLID DISPERSION OF HYDROCHLORTHIAZIDE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp1229-1244, December 2018, Available at : http://www.jetir.org/papers/JETIREB06148.pdf




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