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Published in:

Volume 5 Issue 12
December-2018
eISSN: 2349-5162

Unique Identifier

JETIREC06030

Page Number

273-278

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Title

HAC1 is expressed in Candida parapsilosis-a human fungal pathogen

ISSN

2349-5162

Cite This Article

"HAC1 is expressed in Candida parapsilosis-a human fungal pathogen", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.273-278, December 2018, Available :http://www.jetir.org/papers/JETIREC06030.pdf

Abstract

Candida parapsilosis an opportunistic pathogen, exist as a human commensal. It is the second most common cause of nosocomial candidemia and is showing increased resistance to the existing drugs. It is postulated that increased resistance is due to active ER stress response pathway. In this report, we have characterized the key molecule of this pathway HAC1 and found that it is expressed in ER stress conditions. It is susceptible to UPR stress inducer, suggesting perhaps it is functional in this organism. Since the UPR pathway is responsible for fungal pathogenesis we envision further characterization will suggest methods for immunotherapy.

Key Words

Candida parapsilosis, HAC1, ER stress response, RT-PCR

Cite This Article

"HAC1 is expressed in Candida parapsilosis-a human fungal pathogen", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp273-278, December 2018, Available at : http://www.jetir.org/papers/JETIREC06030.pdf

Publication Details

Published Paper ID: JETIREC06030
Registration ID: 233717
Published In: Volume 5 | Issue 12 | Year December-2018
DOI (Digital Object Identifier):
Page No: 273-278
ISSN Number: 2349-5162

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Cite This Article

"HAC1 is expressed in Candida parapsilosis-a human fungal pathogen", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp273-278, December 2018, Available at : http://www.jetir.org/papers/JETIREC06030.pdf




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