• Rashmi Kumari
• M. Amin-ul Mannan

Candida parapsilosis an opportunistic pathogen, exist as a human commensal. It is the second most common cause of nosocomial candidemia and is showing increased resistance to the existing drugs. It is postulated that increased resistance is due to active ER stress response pathway. In this report, we have characterized the key molecule of this pathway HAC1 and found that it is expressed in ER stress conditions. It is susceptible to UPR stress inducer, suggesting perhaps it is functional in this organism. Since the UPR pathway is responsible for fungal pathogenesis we envision further characterization will suggest methods for immunotherapy.

Candida parapsilosis, HAC1, ER stress response, RT-PCR

"HAC1 is expressed in Candida parapsilosis-a human fungal pathogen", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.273-278, December 2018, Available :http://www.jetir.org/papers/JETIREC06030.pdf

"HAC1 is expressed in Candida parapsilosis-a human fungal pathogen", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp273-278, December 2018, Available at : http://www.jetir.org/papers/JETIREC06030.pdf