• Sanam Dadwal
• Rajesh Kumar
• Sheetu Wadhwa
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Nearly 60-70 % of the synthesized drug candidates are found to be poorly water-soluble and low permeable from the gastrointestinal tract (GIT). Owing to this, formulation scientists and researchers are adopting various strategies to enhance the solubility as well as absorption of these drugs. This review article focuses on the biopharmaceutical classification system (BCS) with special emphasis on BCS class III drugs, limitations of several conventional techniques and the benefits of employing newer approaches such as like self emulsifying drug delivery systems, microspheres, beads, nanoparticles, suppositories, and permeation enhancers. Along with this, the article also highlights on the various studies carried out by formulation scientists to solve the problems associated with BCS class drugs.

BCS, 5 FU, Oral, solubility, permeability

"Formulation strategies to improve the permeability of BCS class ӀӀӀ drugs: Special emphasis on 5 Fluorouracil", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.822-830, December 2018, Available :http://www.jetir.org/papers/JETIREC06099.pdf

"Formulation strategies to improve the permeability of BCS class ӀӀӀ drugs: Special emphasis on 5 Fluorouracil", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp822-830, December 2018, Available at : http://www.jetir.org/papers/JETIREC06099.pdf