• Randhir Vishwakarma
• sarthak Koyande
• Supriya Kamble
• Preeti Sharma

India has a long tradition of practicing ethnobotany. The bioactive secondary metabolites in plants have diverse pharmacological activities and hence always been used as traditional medicine to treat various ailments. There is dire need of drugs that are cost effective, has less or no side effects, synthesized sustainably, do not pose drug resistance issue and has same effectiveness as synthetic medicine available in the market. The study carried out on leaf extract of various plants puts some lights on potent secondary metabolites and their analysis as pharmacological agent. The anti-amylase drug helps in prevention of prolonged hyperglycemic condition in diabetic patients, thrombolytic drug is used in the treatment of thrombosis & antiplaque drug is used for treating dental caries by inhibiting plaque formation. The study was aimed to check & compare the anti-amylase, thrombolytic & antiplaque activity of methanolic leaf extract of Garcinia indica, Psidium guajava & Artocarpus heterophyllus. Soxhlet extraction of these plant leaves was done using a polar solvent, methanol & the powder obtained after drying the extracts in hot air oven were used as sample for phytochemical screening, anti-amylase activity detection using DNSA method, thrombolytic assay & antimicrobial susceptibility testing (AST). G. indica, P. guajava & A. heterophyllus showed 66.87%,50.38% & 48.83% inhibition of amylase enzyme (anti-amylase activity) while 53.67%,39.24% & 36.25% clot lysis (thrombolytic activity) were found respectively. Streptokinase was used as positive control for thrombolysis. Anti-plaque activity was found only in G. indica extract.

Anti-amylase, Hyperglycemic, Thrombosis, Dental caries, Antimicrobial susceptibility testing

"COMPARATIVE STUDY OF PHARMACOLOGICAL & THROMBOLYTIC ACTIVITY OF PLANT LEAVES EXTRACT (Garcinia indica, Psidium guajava, Artocarpus heterophyllus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.8-14, November-2020, Available :http://www.jetir.org/papers/JETIREI06002.pdf

"COMPARATIVE STUDY OF PHARMACOLOGICAL & THROMBOLYTIC ACTIVITY OF PLANT LEAVES EXTRACT (Garcinia indica, Psidium guajava, Artocarpus heterophyllus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp8-14, November-2020, Available at : http://www.jetir.org/papers/JETIREI06002.pdf