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Published in:

Volume 5 Issue 12
December-2018
eISSN: 2349-5162

Unique Identifier

JETIRQ006013

Page Number

57-62

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Title

The Prevalence and Patterns of Resistance to Primary Line of Anti-Tubercular Drugs In Patients on Category-Ii Regimen of RNTCP

ISSN

2349-5162

Cite This Article

"The Prevalence and Patterns of Resistance to Primary Line of Anti-Tubercular Drugs In Patients on Category-Ii Regimen of RNTCP", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.57-62, December-2018, Available :http://www.jetir.org/papers/JETIRQ006013.pdf

Abstract

Background: RNTCP uses short course anti-tubercular (ATT) chemotherapy given intermittently under direct observation (DOTS). Isoniazid (H), Rifampicin(R), Pyrazinamide(Z), Ethambutol(E) and Streptomycin(S) form part of Category-I (2H3R3Z3E3 + 4H3R3) and Category-II (2H3R3Z3E3S3 + 1H3R3Z3E3 + 5H3R3E3) regimen, which are recommended for treatment of new and previously treated tuberculosis patients respectively. There is however concern regarding effectiveness of category-II regimen especially in failure cases. Aim: Objective of the study was to determine the prevalence and pattern of anti-tubercular drug(ATT) resistance in category-II or retreatment patients. Settings: Tertiary teaching hospital Design: Non-randomised prospective study of all patients presenting to DOTS centre and started on category-II treatment. Material and Methods: In our study, all the patients registered under category-II at RNTCP centre over a one-year period were included. Sputum sample was collected for C/S mycobacterium tuberculosis while starting treatment and at the end of 3 months of treatment. Acid-fast bacilli staining of sputum was done by Zeihl-Nelson's Method, culture by modified Lowenstein-Jensen's medium and resistance testing was done by proportion method. Results: 103 patients were registered under category-II. The culture results are available for 87 patients. Amongst, 65.5% were culture negative or pre-treatment susceptible to ATT. MDR-TB was observed in 10.3%, 8.2% and 23% of relapse, treatment after default (TAD) and failure subcategories respectively. Resistance to H, S, R, E, Z were 24.1%,17.2%,16.1%, 5.7% and 17.2% respectively. Emergence of resistance to Rifampicin was seen in 3.8% cases following category-II treatment. Conclusions: 10.35% of all Retreatment regimen patients had Multi-Drug resistant Tuberculosis (MDR-TB). Percentage of MDR-TB was 10.3%, 8.2% and 23% among relapse, TAD and failures subcategories respectively Approval Ethics application site: Ethics Committee, King George Medical University.

Key Words

RNTCP, DOTS, Category 2, Retreatment regimen, Tuberculosis, Resistance, Antitubercular treatment.

Cite This Article

"The Prevalence and Patterns of Resistance to Primary Line of Anti-Tubercular Drugs In Patients on Category-Ii Regimen of RNTCP", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp57-62, December-2018, Available at : http://www.jetir.org/papers/JETIRQ006013.pdf

Publication Details

Published Paper ID: JETIRQ006013
Registration ID: 193137
Published In: Volume 5 | Issue 12 | Year December-2018
DOI (Digital Object Identifier):
Page No: 57-62
ISSN Number: 2349-5162

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Cite This Article

"The Prevalence and Patterns of Resistance to Primary Line of Anti-Tubercular Drugs In Patients on Category-Ii Regimen of RNTCP", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp57-62, December-2018, Available at : http://www.jetir.org/papers/JETIRQ006013.pdf




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