• Ashish G Lonkar
• Balaji N Thakare
• Ashish D Tale
• Yuvraj L Pandhare

The 1,2,4-Triazole nucleus and there fused heterocyclic derivatives are associated with various pharmacological activities and are potential linker moieties. The derivatives of 2,4-Dihydro-4-{4-[4-(4-(3-Chloropropan-One)Phenyl)-1-Piperazinyl] Phenyl}-2-(1-Methylpropyl)-3h-1,2,4-Triazole-3-One were synthesized and the structure of synthesized compound confirmed by TLC and spectroscopic techniques like 1H NMR, IR and mass spectrometry. All the synthesized compounds were screened for antibacterial and anti-fungal activities using agar well diffusion method against Escherichia coli, Staphylococcus aureus, Pseudomonas aerugenosa and Klepsiella pneumoniae bacterial strain and Candida albicans, and Aspergillus Niger pathogenic fungi at various concentration such as 50 µg/ml, 100 µg/ml, 200 µg/ml, 250 µg/ml and 300 µg/ml. The reference standard use for bacterium was Amikacine sulphate (10 µg/ml) and for fungi was ketoconazole (15 µg/ml). It has been observed that the entire tested compound’s showed mild to moderate activity against tested bacteria and fungi. Some of them have good activity at observed concentration.

Triazole, 1H NMR, IR, mass spectrometry, antibacterial and antifungal.

"Synthesis, Characterization and Pharmacological Evaluation of Antimicrobial Activity of Novel 1,2,4-Triazole Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 9, page no.978-987, September-2018, Available :http://www.jetir.org/papers/JETIR1809938.pdf

"Synthesis, Characterization and Pharmacological Evaluation of Antimicrobial Activity of Novel 1,2,4-Triazole Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 9, page no. pp978-987, September-2018, Available at : http://www.jetir.org/papers/JETIR1809938.pdf