UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908B51


Registration ID:
230150

Page Number

373-401

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Title

Formulation and Evaluation of Transdermal Patch from Lamivudine and Stavudine-Loaded Ethosomes

Abstract

The purpose of the work was to formulate and evaluate the Lamivudine and Stavudine-loaded ethosome transdermal patches for the controlled delivery of the drug in the body. Patches were formulated using various ratios of polymer HPMCK15M, (PVPK30) Polyvinyl Pyrrolidone and Ethyl Cellulose. Transdermal patches were formulated by solvent evaporation method. The drug polymer interaction was investigated by FTIR and the results indicated no incompatibility. Lamivudine and Stavudine patches were evaluated for various parameters like thickness, folding endurance, percentage moisture loss, percentage moisture absorption, drug content uniformity, stability studies, in vitro skin permeation, skin irritation test. All formulations possess excellent physicochemical properties and exhibited negligible skin irritation with good physical stability. Permeation study was performed by using modified Franz diffusion cells. On the basis of drug release and physicochemical values, formulation TF5 was considered as an optimized formulation which shows higher percentage of drug release at 12 hours. Percentage drug release of Lamivudine and Stavudine-loaded ethosome transdermal patches was observed to be 95.24% Lamivudine and 94.24 % Stavudine drug at 12 hrs. Release kinetics studies revealed that the drug release from formulations TF5 followed Higuchi kinetics.

Key Words

Lamivudine, Stavudine, ethosome,Transdermal patches, HPMCK15M, In vitro

Cite This Article

"Formulation and Evaluation of Transdermal Patch from Lamivudine and Stavudine-Loaded Ethosomes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.373-401, June-2019, Available :http://www.jetir.org/papers/JETIR1908B51.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation and Evaluation of Transdermal Patch from Lamivudine and Stavudine-Loaded Ethosomes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp373-401, June-2019, Available at : http://www.jetir.org/papers/JETIR1908B51.pdf

Publication Details

Published Paper ID: JETIR1908B51
Registration ID: 230150
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 373-401
Country: bhopal, M.P, India .
Area: Pharmacy
ISSN Number: 2349-5162


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