UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908B73


Registration ID:
234185

Page Number

572-578

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Title

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF HOLOSTEMMA ANNULARE

Abstract

As per the Phytochemical investigation and literaturereviewHolostemmaannulare had many active constituents especially methanolic extract have more number and quantity of active components. The methanolic extract was used for study, the extract was prepared and tested against Paracetamol induced liver damage in experimental rats. Changes were observed in the biochemical markers like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and Bilirubin. The effects of the extracts were compared with that of standard drug sylimarin(100 mg/kg) treated group. Phytochemical investigations showed the presence of alkaloids, flavonoids, terpenods, saponins and absence of glycosides, the results suggest that Paracetamol (2g/kg) elevated the levels of AST, ALT, ALP and Bilirubin. Treatment of different doses (150mg/kg and 250mg/kg) of Holostemmaannulare extract ameliorated the effects of the Hepatotoxins and significantly (p<0.05) reduced elevated levels of Biochemical markers

Key Words

Hepatoprotective, Antioxidant, Plant extract AST, ALT, ALP, Bilirubin

Cite This Article

"PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF HOLOSTEMMA ANNULARE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.572-578, June 2019, Available :http://www.jetir.org/papers/JETIR1908B73.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF HOLOSTEMMA ANNULARE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp572-578, June 2019, Available at : http://www.jetir.org/papers/JETIR1908B73.pdf

Publication Details

Published Paper ID: JETIR1908B73
Registration ID: 234185
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 572-578
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162


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