UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908D47


Registration ID:
309106

Page Number

1168-1175

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Title

Quantitative estimation of phytochemicals and in vitro antidiabetic activity of chloroform fraction of Marrubium vulgare L. leaf.

Abstract

Diabetes mellitus a chronic metabolic disorder characterized by hyperglycaemia together with altered carbohydrate, lipid and protein metabolism due to inadequate amount of insulin secretion by pancreas. Various approaches are used to have a control/curb over this increased life threatened disease. Among these approaches, one of the most widely used one is, use of natural inhibitors which reduces gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α- amylase and α-glucosidase. Through these strategic managements post prandial increase of blood glucose after a mixed carbohydrate diet can be reduced significantly. Keeping this therapeutic approach in mind we estimated the phytochemical contents of methanolic extract of M. vulgare L. leaf and its chloroform fraction and evaluate the vitro antidiabetic activity of chloroform fraction. The assay suggested that chloroform fraction containing highest content of terpenoids (636.81 ± 22.95 mg Le/g extract) exhibited dose dependent increase in inhibitory effect on α- amylase enzymes (IC50 487.33±2.65 g/ml) and α-glucosidase (IC50 392.95±7.38 g/ml). From the current study in which chloroform fraction (Chf fr) showing significant inhibitory effect on carbohydrate digestive enzymes, we depicted that the activity could be due to presence of terpenoids.

Key Words

alpha-amylase, alpha-glucosidase, diterpenoids, total phenol content, total terpenoid content

Cite This Article

"Quantitative estimation of phytochemicals and in vitro antidiabetic activity of chloroform fraction of Marrubium vulgare L. leaf.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1168-1175, June-2019, Available :http://www.jetir.org/papers/JETIR1908D47.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Quantitative estimation of phytochemicals and in vitro antidiabetic activity of chloroform fraction of Marrubium vulgare L. leaf.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1168-1175, June-2019, Available at : http://www.jetir.org/papers/JETIR1908D47.pdf

Publication Details

Published Paper ID: JETIR1908D47
Registration ID: 309106
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.26954
Page No: 1168-1175
Country: Bhopal, Madhya Pradesh, India .
Area: Science
ISSN Number: 2349-5162


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